人 Survivin 抗体对
01AB02537
Baculoviral IAP repeat-containing protein 5 (BIRC5), commonly known as survivin, is a crucial member of the inhibitor of apoptosis (IAP) family. BIRC5 is involved in cell cycle regulation and is specifically expressed during the G2-M phase, highlighting its role in mitosis. Furthermore, this protein plays a significant role in inhibiting apoptosis, thereby promoting cell survival, particularly in cancer cells. BIRC5 is characterized by its ability to bind and inhibit caspases, which are essential for the apoptotic process. Its expression is notably elevated in various cancers, including breast, prostate, and colorectal cancers, where it contributes to tumor growth and resistance to chemotherapy. In addition to cancer, aberrant BIRC5 expression has been linked to other diseases, such as cardiovascular diseases and chronic inflammatory conditions.
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技术参数
- 靶点基因名
- BIRC5
- 基因别名
- API4; IAP4
- 蛋白别名
- baculoviral IAP repeat containing 5; Survivin
- UniProt
- O15392
- 物种
- Human
产品详情
- 靶点名称
- Survivin
- 蛋白名称
- baculoviral IAP repeat containing 5
- 蛋白别名
- Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin
- 靶点基因名
- BIRC5
- 基因别名
- API4; IAP4
- UniProt
- O15392
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Baculoviral IAP repeat-containing protein 5 (BIRC5), commonly known as survivin, is a crucial member of the inhibitor of apoptosis (IAP) family. BIRC5 is involved in cell cycle regulation and is specifically expressed during the G2-M phase, highlighting its role in mitosis. Furthermore, this protein plays a significant role in inhibiting apoptosis, thereby promoting cell survival, particularly in cancer cells. BIRC5 is characterized by its ability to bind and inhibit caspases, which are essential for the apoptotic process. Its expression is notably elevated in various cancers, including breast, prostate, and colorectal cancers, where it contributes to tumor growth and resistance to chemotherapy. In addition to cancer, aberrant BIRC5 expression has been linked to other diseases, such as cardiovascular diseases and chronic inflammatory conditions.