人 SULT1C2 抗体对
01AB00599
Sulfotransferase family 1C member 2 (SULT1C2) is a cytosolic enzyme encoded by the SULT1C2 gene, primarily involved in the sulfonation of hormones, neurotransmitters, drugs, and xenobiotics using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a sulfate donor. This phase II detoxification enzyme facilitates the metabolism and excretion of various compounds, including potential carcinogens. SULT1C2 is structurally characterized by a conserved sulfotransferase domain and is expressed in fetal kidney and adult tissues like the stomach and thyroid. Its activity varies due to genetic polymorphisms, influencing individual responses to toxins and drugs. Dysregulation of SULT1C2 has been implicated in disease, particularly cancer. Overexpression in gastric and thyroid tissues is associated with increased susceptibility to carcinomas, potentially due to its role in activating procarcinogens or altering hormone signaling. For instance, elevated SULT1C2 levels may promote thyroid tumorigenesis by modifying estrogen metabolism. Additionally, genetic variants of SULT1C2 are linked to colorectal and hepatocellular cancer risks, highlighting its dual role in detoxification and carcinogen activation.
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技术参数
- 靶点基因名
- SULT1C2
- 基因别名
- SULT1C1
- 蛋白别名
- sulfotransferase family 1C member 2; SULT1C2
- UniProt
- O00338
- 物种
- Human
产品详情
- 靶点名称
- SULT1C2
- 蛋白名称
- sulfotransferase family 1C member 2
- 蛋白别名
- Sulfotransferase 1C2; ST1C2; Sulfotransferase 1C1; SULT1C#1; humSULTC2
- 靶点基因名
- SULT1C2
- 基因别名
- SULT1C1
- UniProt
- O00338
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Sulfotransferase family 1C member 2 (SULT1C2) is a cytosolic enzyme encoded by the SULT1C2 gene, primarily involved in the sulfonation of hormones, neurotransmitters, drugs, and xenobiotics using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a sulfate donor. This phase II detoxification enzyme facilitates the metabolism and excretion of various compounds, including potential carcinogens. SULT1C2 is structurally characterized by a conserved sulfotransferase domain and is expressed in fetal kidney and adult tissues like the stomach and thyroid. Its activity varies due to genetic polymorphisms, influencing individual responses to toxins and drugs. Dysregulation of SULT1C2 has been implicated in disease, particularly cancer. Overexpression in gastric and thyroid tissues is associated with increased susceptibility to carcinomas, potentially due to its role in activating procarcinogens or altering hormone signaling. For instance, elevated SULT1C2 levels may promote thyroid tumorigenesis by modifying estrogen metabolism. Additionally, genetic variants of SULT1C2 are linked to colorectal and hepatocellular cancer risks, highlighting its dual role in detoxification and carcinogen activation.