人 STXBP3 抗体对
01AB01604
Syntaxin binding protein 3 (STXBP3), also known as Munc18c, is a cytosolic protein that regulates membrane fusion by binding to syntaxin 3 (STX3), a Qa-SNARE protein involved in vesicle docking and exocytosis. STXBP3 interacts specifically with syntaxins to control SNARE complex assembly, essential for processes like insulin-stimulated GLUT4 vesicle fusion in adipocytes and muscle cells, thereby regulating glucose uptake. Structurally, STXBP3 modulates syntaxin conformation, influencing vesicle trafficking and exocytosis efficiency. It also plays roles in neutrophil degranulation and platelet aggregation by negatively regulating calcium-dependent exocytosis. Importantly, STXBP3-mediated regulation of vesicle fusion impacts insulin secretion and glucose homeostasis, linking it to metabolic disorders such as type 2 diabetes. Additionally, its interaction with ubiquitin and involvement in endosomal trafficking suggest broader roles in membrane protein sorting. Dysregulation of STXBP3 function can impair insulin secretion and vesicle trafficking, contributing to metabolic disease pathogenesis.
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技术参数
- 靶点基因名
- STXBP3
- 蛋白别名
- syntaxin binding protein 3; STXBP3
- UniProt
- O00186
- 物种
- Human
产品详情
- 靶点名称
- STXBP3
- 蛋白名称
- syntaxin binding protein 3
- 蛋白别名
- Syntaxin-binding protein 3; Platelet Sec1 protein; PSP; Protein unc-18 homolog 3; Unc18-3; Protein unc-18 homolog C; Unc-18C
- 靶点基因名
- STXBP3
- UniProt
- O00186
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Syntaxin binding protein 3 (STXBP3), also known as Munc18c, is a cytosolic protein that regulates membrane fusion by binding to syntaxin 3 (STX3), a Qa-SNARE protein involved in vesicle docking and exocytosis. STXBP3 interacts specifically with syntaxins to control SNARE complex assembly, essential for processes like insulin-stimulated GLUT4 vesicle fusion in adipocytes and muscle cells, thereby regulating glucose uptake. Structurally, STXBP3 modulates syntaxin conformation, influencing vesicle trafficking and exocytosis efficiency. It also plays roles in neutrophil degranulation and platelet aggregation by negatively regulating calcium-dependent exocytosis. Importantly, STXBP3-mediated regulation of vesicle fusion impacts insulin secretion and glucose homeostasis, linking it to metabolic disorders such as type 2 diabetes. Additionally, its interaction with ubiquitin and involvement in endosomal trafficking suggest broader roles in membrane protein sorting. Dysregulation of STXBP3 function can impair insulin secretion and vesicle trafficking, contributing to metabolic disease pathogenesis.