人 STX8 抗体对
01AB01851
Syntaxin 8 (STX8) is a member of the syntaxin family of proteins involved in intracellular vesicle trafficking, particularly mediating protein transport between early and late endosomes as well as retrograde transport from the Golgi to the endoplasmic reticulum. It contains three N-terminal helices, a SNARE domain, and a C-terminal transmembrane domain, and forms SNARE complexes with proteins such as syntaxin 7, vti1b, and endobrevin, playing a key role in homotypic fusion of late endosomes. STX8 also modulates the trafficking of specific proteins like the TrkA receptor and the potassium channel TASK-1 by influencing their surface expression through endosomal and post-biosynthetic pathways. In terms of disease relevance, alterations in STX8-mediated trafficking impact cellular functions such as receptor surface levels that can affect signaling; for example, defects in STX8 influence cellular transport processes critical in kidney function and immune cell cytotoxicity, linking STX8 dysfunction to pathologies involving vesicle trafficking and cellular transport disorders.
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技术参数
- 靶点基因名
- STX8
- 蛋白别名
- syntaxin 8; STX8
- UniProt
- Q9UNK0
- 物种
- Human
产品详情
- 靶点名称
- STX8
- 蛋白名称
- syntaxin 8
- 蛋白别名
- Syntaxin-8
- 靶点基因名
- STX8
- UniProt
- Q9UNK0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Syntaxin 8 (STX8) is a member of the syntaxin family of proteins involved in intracellular vesicle trafficking, particularly mediating protein transport between early and late endosomes as well as retrograde transport from the Golgi to the endoplasmic reticulum. It contains three N-terminal helices, a SNARE domain, and a C-terminal transmembrane domain, and forms SNARE complexes with proteins such as syntaxin 7, vti1b, and endobrevin, playing a key role in homotypic fusion of late endosomes. STX8 also modulates the trafficking of specific proteins like the TrkA receptor and the potassium channel TASK-1 by influencing their surface expression through endosomal and post-biosynthetic pathways. In terms of disease relevance, alterations in STX8-mediated trafficking impact cellular functions such as receptor surface levels that can affect signaling; for example, defects in STX8 influence cellular transport processes critical in kidney function and immune cell cytotoxicity, linking STX8 dysfunction to pathologies involving vesicle trafficking and cellular transport disorders.