人 STX7 抗体对
01AB04159
Syntaxin-7 (STX7) is a member of the syntaxin family of proteins, which are integral components of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex involved in membrane fusion processes. STX7 is primarily localized to endosomal membranes and plays a crucial role in mediating vesicle trafficking and fusion within the endosomal-lysosomal pathway. Its function is essential for the recycling of synaptic vesicles and the delivery of cargo to lysosomes. Dysregulation or mutations in STX7 have been associated with several diseases, including Hermansky-Pudlak syndrome, characterized by oculocutaneous albinism and bleeding disorders due to impaired lysosomal function. Additionally, STX7 has been implicated in neurodegenerative diseases, such as Alzheimer's disease, where its dysfunction may contribute to amyloid-beta accumulation.
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技术参数
- 靶点基因名
- STX7
- 蛋白别名
- syntaxin 7; STX7
- UniProt
- O15400
- 物种
- Human
产品详情
- 靶点名称
- STX7
- 蛋白名称
- syntaxin 7
- 蛋白别名
- Syntaxin-7
- 靶点基因名
- STX7
- UniProt
- O15400
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Syntaxin-7 (STX7) is a member of the syntaxin family of proteins, which are integral components of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex involved in membrane fusion processes. STX7 is primarily localized to endosomal membranes and plays a crucial role in mediating vesicle trafficking and fusion within the endosomal-lysosomal pathway. Its function is essential for the recycling of synaptic vesicles and the delivery of cargo to lysosomes. Dysregulation or mutations in STX7 have been associated with several diseases, including Hermansky-Pudlak syndrome, characterized by oculocutaneous albinism and bleeding disorders due to impaired lysosomal function. Additionally, STX7 has been implicated in neurodegenerative diseases, such as Alzheimer's disease, where its dysfunction may contribute to amyloid-beta accumulation.