人 STK4 抗体对
01AB02104
Serine/threonine kinase 4 (STK4), also known as MST1, is a cytoplasmic kinase structurally related to yeast Ste20p and is a central component of the Hippo signaling pathway, which is crucial for organ size control, tumor suppression, and regulation of cell proliferation and apoptosis. STK4 phosphorylates various substrates, including myelin basic protein, histone H2B, and FOXO transcription factors, and is activated by caspase cleavage during apoptosis, leading to chromatin condensation and DNA fragmentation. It also modulates cell polarity, migration, and epithelial-to-mesenchymal transition, with high STK4 expression linked to favorable outcomes in certain cancers. Pathogenic variants in STK4 cause an autosomal recessive immunodeficiency characterized by persistent viral, bacterial, and fungal infections, lymphopenia, autoimmune cytopenias, and impaired leukocyte migration and adhesion. Affected individuals often present with HPV-associated epidermodysplasia verruciformis, increased immunoglobulin G, and require targeted antimicrobial and immunosuppressive therapies.
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技术参数
- 靶点基因名
- STK4
- 基因别名
- KRS2; MST1
- 蛋白别名
- serine/threonine kinase 4; STK4
- UniProt
- Q13043
- 物种
- Human
产品详情
- 靶点名称
- STK4
- 蛋白名称
- serine/threonine kinase 4
- 蛋白别名
- Serine/threonine-protein kinase 4; Mammalian STE20-like protein kinase 1; MST-1; STE20-like kinase MST1; Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit; MST1/N); Serine/threonine-protein kinase 4 18kDa subunit; MST1/C]
- 靶点基因名
- STK4
- 基因别名
- KRS2; MST1
- UniProt
- Q13043
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Serine/threonine kinase 4 (STK4), also known as MST1, is a cytoplasmic kinase structurally related to yeast Ste20p and is a central component of the Hippo signaling pathway, which is crucial for organ size control, tumor suppression, and regulation of cell proliferation and apoptosis. STK4 phosphorylates various substrates, including myelin basic protein, histone H2B, and FOXO transcription factors, and is activated by caspase cleavage during apoptosis, leading to chromatin condensation and DNA fragmentation. It also modulates cell polarity, migration, and epithelial-to-mesenchymal transition, with high STK4 expression linked to favorable outcomes in certain cancers. Pathogenic variants in STK4 cause an autosomal recessive immunodeficiency characterized by persistent viral, bacterial, and fungal infections, lymphopenia, autoimmune cytopenias, and impaired leukocyte migration and adhesion. Affected individuals often present with HPV-associated epidermodysplasia verruciformis, increased immunoglobulin G, and require targeted antimicrobial and immunosuppressive therapies.