人 STEAP1 抗体对
01AB01599
STEAP family member 1 (STEAP1) is a six-transmembrane domain protein composed of 339 amino acids, encoded by a gene located on chromosome 7q21.13. Structurally, STEAP1 features two intracellular and three extracellular loops, with both termini facing the cytoplasm, and contains a C-terminal domain homologous to b-type cytochrome metalloreductases, suggesting a role in electron transport. Recent studies indicate that STEAP1 can participate in iron metabolism by transferring electrons through its B-heme group and potentially forming heterotrimers with STEAP4, which possesses NADPH-binding capability. Cryo-EM analysis reveals a trimeric structure with conserved FAD- and heme-binding sites, supporting its function as a transmembrane oxidoreductase involved in iron reduction. STEAP1 is predominantly expressed in prostate tissue and is highly upregulated in various cancers, particularly prostate cancer, where it enhances cell proliferation and metastatic potential.
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技术参数
- 靶点基因名
- STEAP1
- 基因别名
- PRSS24; STEAP
- 蛋白别名
- STEAP family member 1; STEAP1
- UniProt
- Q9UHE8
- 物种
- Human
产品详情
- 靶点名称
- STEAP1
- 蛋白名称
- STEAP family member 1
- 蛋白别名
- STEAP1 protein; Six-transmembrane epithelial antigen of prostate 1
- 靶点基因名
- STEAP1
- 基因别名
- PRSS24; STEAP
- UniProt
- Q9UHE8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
STEAP family member 1 (STEAP1) is a six-transmembrane domain protein composed of 339 amino acids, encoded by a gene located on chromosome 7q21.13. Structurally, STEAP1 features two intracellular and three extracellular loops, with both termini facing the cytoplasm, and contains a C-terminal domain homologous to b-type cytochrome metalloreductases, suggesting a role in electron transport. Recent studies indicate that STEAP1 can participate in iron metabolism by transferring electrons through its B-heme group and potentially forming heterotrimers with STEAP4, which possesses NADPH-binding capability. Cryo-EM analysis reveals a trimeric structure with conserved FAD- and heme-binding sites, supporting its function as a transmembrane oxidoreductase involved in iron reduction. STEAP1 is predominantly expressed in prostate tissue and is highly upregulated in various cancers, particularly prostate cancer, where it enhances cell proliferation and metastatic potential.