人 STAMBP 抗体对
01AB03682
STAM-binding protein (STAMBP), also known as AMSH, is a deubiquitinating enzyme that plays a vital role in endosomal sorting and trafficking. It interacts with endosomal sorting complexes required for transport (ESCRTs), facilitating the removal of ubiquitin from target proteins, which is essential for maintaining protein homeostasis within cells. STAMBP's functions extend beyond protein degradation; it is involved in various signaling pathways, including those related to cell growth and angiogenesis. Dysregulation of STAMBP has been linked to several diseases. Notably, mutations in the STAMBP gene are associated with microcephaly-capillary malformation syndrome, characterized by developmental delays, seizures, and vascular abnormalities due to impaired protein degradation and signaling. Additionally, STAMBP has been implicated in cancer progression, particularly in triple-negative breast cancer (TNBC), where it promotes tumor growth by stabilizing the actin-binding protein RAI14 through deubiquitination.
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技术参数
- 靶点基因名
- STAMBP
- 基因别名
- AMSH
- 蛋白别名
- STAM binding protein; STAMBP
- UniProt
- O95630
- 物种
- Human
产品详情
- 靶点名称
- STAMBP
- 蛋白名称
- STAM binding protein
- 蛋白别名
- STAM-binding protein; Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase
- 靶点基因名
- STAMBP
- 基因别名
- AMSH
- UniProt
- O95630
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
STAM-binding protein (STAMBP), also known as AMSH, is a deubiquitinating enzyme that plays a vital role in endosomal sorting and trafficking. It interacts with endosomal sorting complexes required for transport (ESCRTs), facilitating the removal of ubiquitin from target proteins, which is essential for maintaining protein homeostasis within cells. STAMBP's functions extend beyond protein degradation; it is involved in various signaling pathways, including those related to cell growth and angiogenesis. Dysregulation of STAMBP has been linked to several diseases. Notably, mutations in the STAMBP gene are associated with microcephaly-capillary malformation syndrome, characterized by developmental delays, seizures, and vascular abnormalities due to impaired protein degradation and signaling. Additionally, STAMBP has been implicated in cancer progression, particularly in triple-negative breast cancer (TNBC), where it promotes tumor growth by stabilizing the actin-binding protein RAI14 through deubiquitination.