抗人 ST6GALNAC5 抗体对
01AB01359
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ST6GALNAC5) is a Golgi type II transmembrane glycosyltransferase enzyme consisting of 316 amino acids with a molecular mass of approximately 36.4 kDa. It catalyzes the transfer of sialic acid to cell surface proteins and is specifically involved in the biosynthesis of ganglioside GD1α from GM1b, predominantly expressed in brain tissue. ST6GALNAC5 modulates cell-cell interactions and influences receptor tyrosine kinases via membrane microdomain formation. Functionally, it plays a role in cell junction regulation, differentiation, and metastasis, particularly in prostate and breast cancers. Overexpression of ST6GALNAC5 promotes cancer cell invasion and proliferation by activating pathways such as MAPK/ERK1/2. Notably, it facilitates breast cancer brain metastasis by enabling cancer cells to cross the blood-brain barrier, while its role may vary depending on cancer context, sometimes inhibiting glioma invasiveness.
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技术参数
- 靶点基因名
- ST6GALNAC5
- 基因别名
- SIAT7E
- 蛋白别名
- ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GALNAC5
- UniProt
- Q9BVH7
- 物种
- Human
产品详情
- 靶点名称
- ST6GALNAC5
- 蛋白名称
- ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
- 蛋白别名
- Alpha-N-acetylgalactosaminide alpha-2; 6-sialyltransferase 5; GD1 alpha synthase; GalNAc alpha-2; 6-sialyltransferase V; ST6GalNAc V; ST6GalNAcV; Sialyltransferase 7E; SIAT7-E
- 靶点基因名
- ST6GALNAC5
- 基因别名
- SIAT7E
- UniProt
- Q9BVH7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ST6GALNAC5) is a Golgi type II transmembrane glycosyltransferase enzyme consisting of 316 amino acids with a molecular mass of approximately 36.4 kDa. It catalyzes the transfer of sialic acid to cell surface proteins and is specifically involved in the biosynthesis of ganglioside GD1α from GM1b, predominantly expressed in brain tissue. ST6GALNAC5 modulates cell-cell interactions and influences receptor tyrosine kinases via membrane microdomain formation. Functionally, it plays a role in cell junction regulation, differentiation, and metastasis, particularly in prostate and breast cancers. Overexpression of ST6GALNAC5 promotes cancer cell invasion and proliferation by activating pathways such as MAPK/ERK1/2. Notably, it facilitates breast cancer brain metastasis by enabling cancer cells to cross the blood-brain barrier, while its role may vary depending on cancer context, sometimes inhibiting glioma invasiveness.