人 SRPK2 抗体对
01AB03664
SRSF protein kinase 2 (SRPK2) is a serine/arginine-rich protein kinase that plays a critical role in pre-mRNA splicing by phosphorylating serine/arginine (SR) proteins, which are essential for spliceosome assembly and function. SRPK2 is highly expressed in the brain and is involved in the regulation of alternative splicing, influencing various cellular processes such as cell proliferation, differentiation, and apoptosis. It has been shown to interact with several signaling pathways, including the mTORC1 pathway, which regulates lipid metabolism and affects cancer cell growth. Dysregulation of SRPK2 has been implicated in various diseases, particularly cancer; its overexpression has been associated with poor prognosis in melanoma and other malignancies due to its role in promoting cell migration and invasion.
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技术参数
- 靶点基因名
- SRPK2
- 蛋白别名
- SRSF protein kinase 2; SRPK2
- UniProt
- P78362
- 物种
- Human
产品详情
- 靶点名称
- SRPK2
- 蛋白名称
- SRSF protein kinase 2
- 蛋白别名
- SRSF protein kinase 2; SFRS protein kinase 2; Serine/arginine-rich protein-specific kinase 2; SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
- 靶点基因名
- SRPK2
- UniProt
- P78362
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
SRSF protein kinase 2 (SRPK2) is a serine/arginine-rich protein kinase that plays a critical role in pre-mRNA splicing by phosphorylating serine/arginine (SR) proteins, which are essential for spliceosome assembly and function. SRPK2 is highly expressed in the brain and is involved in the regulation of alternative splicing, influencing various cellular processes such as cell proliferation, differentiation, and apoptosis. It has been shown to interact with several signaling pathways, including the mTORC1 pathway, which regulates lipid metabolism and affects cancer cell growth. Dysregulation of SRPK2 has been implicated in various diseases, particularly cancer; its overexpression has been associated with poor prognosis in melanoma and other malignancies due to its role in promoting cell migration and invasion.