人 SRM 抗体对
01AB02308
Spermidine synthase (SRM) is a cytosolic enzyme that catalyzes the final step in the polyamine biosynthetic pathway, converting putrescine and decarboxylated S-adenosylmethionine (dcSAM) into spermidine, a polyamine essential for cell growth and differentiation. The SRM protein is a homodimer with a strong substrate preference for putrescine and minimal activity toward other amines, and it does not require cofactors for its activity. Structurally, it belongs to the aminopropyltransferase family and is highly specific for its substrates, with its mechanism involving a nucleophilic attack by deprotonated putrescine on dcSAM. Dysregulation or inhibition of SRM has been implicated in several diseases, notably Sleeping Sickness (caused by Trypanosoma brucei) and Chagas Disease (caused by Trypanosoma cruzi), as these parasites rely on polyamine biosynthesis for survival, making SRM a potential drug target. Additionally, altered polyamine metabolism, including SRM activity, is associated with cancer and other proliferative disorders due to its role in cellular proliferation and differentiation.
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技术参数
- 靶点基因名
- SRM
- 基因别名
- SPS1; SRML1
- 蛋白别名
- spermidine synthase; SRM
- UniProt
- P19623
- 物种
- Human
产品详情
- 靶点名称
- SRM
- 蛋白名称
- spermidine synthase
- 蛋白别名
- Spermidine synthase; SPDSY; Putrescine aminopropyltransferase
- 靶点基因名
- SRM
- 基因别名
- SPS1; SRML1
- UniProt
- P19623
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Spermidine synthase (SRM) is a cytosolic enzyme that catalyzes the final step in the polyamine biosynthetic pathway, converting putrescine and decarboxylated S-adenosylmethionine (dcSAM) into spermidine, a polyamine essential for cell growth and differentiation. The SRM protein is a homodimer with a strong substrate preference for putrescine and minimal activity toward other amines, and it does not require cofactors for its activity. Structurally, it belongs to the aminopropyltransferase family and is highly specific for its substrates, with its mechanism involving a nucleophilic attack by deprotonated putrescine on dcSAM. Dysregulation or inhibition of SRM has been implicated in several diseases, notably Sleeping Sickness (caused by Trypanosoma brucei) and Chagas Disease (caused by Trypanosoma cruzi), as these parasites rely on polyamine biosynthesis for survival, making SRM a potential drug target. Additionally, altered polyamine metabolism, including SRM activity, is associated with cancer and other proliferative disorders due to its role in cellular proliferation and differentiation.