人 SPTB 抗体对
01AB02922
Spectrin beta, erythrocytic (SPTB) encodes the beta-subunit of spectrin, a major component of the red blood cell membrane skeleton. It forms heterodimers with alpha-spectrin to create a lattice that anchors to the plasma membrane via interactions with ankyrin, actin, and protein 4.1. This cytoskeletal network is critical for maintaining the biconcave shape, deformability, and mechanical stability of erythrocytes. Pathogenic variants in SPTB disrupt membrane integrity, leading to hereditary spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. These conditions are characterized by increased red cell fragility, hemolysis, jaundice, and splenomegaly.
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技术参数
- 靶点基因名
- SPTB
- 基因别名
- SPTB1
- 蛋白别名
- spectrin beta, erythrocytic; SPTB
- UniProt
- P11277
- 物种
- Human
产品详情
- 靶点名称
- SPTB
- 蛋白名称
- spectrin beta, erythrocytic
- 蛋白别名
- Spectrin beta chain; erythrocytic; Beta-I spectrin
- 靶点基因名
- SPTB
- 基因别名
- SPTB1
- UniProt
- P11277
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Spectrin beta, erythrocytic (SPTB) encodes the beta-subunit of spectrin, a major component of the red blood cell membrane skeleton. It forms heterodimers with alpha-spectrin to create a lattice that anchors to the plasma membrane via interactions with ankyrin, actin, and protein 4.1. This cytoskeletal network is critical for maintaining the biconcave shape, deformability, and mechanical stability of erythrocytes. Pathogenic variants in SPTB disrupt membrane integrity, leading to hereditary spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. These conditions are characterized by increased red cell fragility, hemolysis, jaundice, and splenomegaly.