人 SPRED2 抗体对
01AB00596
Sprouty related EVH1 domain containing 2 (SPRED2) is a crucial member of the SPRED protein family, characterized by its three functional domains: the N-terminal EVH1 domain, the central c-Kit-binding domain, and the C-terminal Sprouty-related domain. SPRED2 primarily functions as a negative regulator of the MAPK signaling pathway, inhibiting cell proliferation and differentiation in response to growth factors. Its expression is vital in various tissues, particularly in the lungs, where it plays a significant role in managing inflammatory responses and tissue repair processes. Dysregulation of SPRED2 has been linked to several diseases, including pulmonary fibrosis, asthma, and other inflammatory conditions, where its reduced expression can exacerbate disease progression by enhancing epithelial cell proliferation and inflammatory responses. The protein's properties include its ability to form dimers and interact with other signaling molecules, which are essential for its regulatory functions in cellular signaling pathways.
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技术参数
- 靶点基因名
- SPRED2
- 蛋白别名
- sprouty related EVH1 domain containing 2; SPRED2
- UniProt
- Q7Z698
- 物种
- Human
产品详情
- 靶点名称
- SPRED2
- 蛋白名称
- sprouty related EVH1 domain containing 2
- 蛋白别名
- Sprouty-related; EVH1 domain-containing protein 2; Spred-2
- 靶点基因名
- SPRED2
- UniProt
- Q7Z698
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Sprouty related EVH1 domain containing 2 (SPRED2) is a crucial member of the SPRED protein family, characterized by its three functional domains: the N-terminal EVH1 domain, the central c-Kit-binding domain, and the C-terminal Sprouty-related domain. SPRED2 primarily functions as a negative regulator of the MAPK signaling pathway, inhibiting cell proliferation and differentiation in response to growth factors. Its expression is vital in various tissues, particularly in the lungs, where it plays a significant role in managing inflammatory responses and tissue repair processes. Dysregulation of SPRED2 has been linked to several diseases, including pulmonary fibrosis, asthma, and other inflammatory conditions, where its reduced expression can exacerbate disease progression by enhancing epithelial cell proliferation and inflammatory responses. The protein's properties include its ability to form dimers and interact with other signaling molecules, which are essential for its regulatory functions in cellular signaling pathways.