抗人 SPP1 抗体对
01AB02433
Osteopontin (OPN), also known as secreted phosphoprotein-1 (SPP1), is a multifunctional glycoprotein primarily involved in bone remodeling and immune response. It is produced by various cell types, including osteoblasts, macrophages, and lymphocytes, and plays a crucial role in cell adhesion, migration, and survival through its interactions with integrins and the CD44 receptor. In the context of disease, elevated levels of SPP1 have been associated with several conditions, including cancer, where it contributes to tumor progression and metastasis, and chronic inflammatory diseases such as rheumatoid arthritis and interstitial lung diseases. Its expression is notably increased in hepatocellular carcinoma and intrahepatic cholangiocarcinoma, correlating with poor prognosis. Additionally, SPP1 is implicated in cardiovascular diseases, particularly in the remodeling of cardiac tissue following ischemic injury.
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技术参数
- 靶点基因名
- SPP1
- 基因别名
- BNSP; OPN
- 蛋白别名
- secreted phosphoprotein 1; SPP1
- UniProt
- P10451
- 物种
- Human
产品详情
- 靶点名称
- SPP1
- 蛋白名称
- secreted phosphoprotein 1
- 蛋白别名
- Osteopontin; Bone sialoprotein 1; Nephropontin; Secreted phosphoprotein 1; SPP-1; Urinary stone protein; Uropontin
- 靶点基因名
- SPP1
- 基因别名
- BNSP; OPN
- UniProt
- P10451
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Osteopontin (OPN), also known as secreted phosphoprotein-1 (SPP1), is a multifunctional glycoprotein primarily involved in bone remodeling and immune response. It is produced by various cell types, including osteoblasts, macrophages, and lymphocytes, and plays a crucial role in cell adhesion, migration, and survival through its interactions with integrins and the CD44 receptor. In the context of disease, elevated levels of SPP1 have been associated with several conditions, including cancer, where it contributes to tumor progression and metastasis, and chronic inflammatory diseases such as rheumatoid arthritis and interstitial lung diseases. Its expression is notably increased in hepatocellular carcinoma and intrahepatic cholangiocarcinoma, correlating with poor prognosis. Additionally, SPP1 is implicated in cardiovascular diseases, particularly in the remodeling of cardiac tissue following ischemic injury.