抗人 SPOCK1 抗体对
01AB00953
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 (SPOCK1) is a multidomain proteoglycan belonging to the SPARC family, consisting of an N-terminus, follistatin-like domain, extracellular calcium-binding domain, and a C-terminus with thyropin and Kazal-like domains. It contains both heparan and chondroitin sulfate chains, distinguishing it from SPOCK2 and SPOCK3. SPOCK1 is widely expressed in tissues including brain, cartilage, and vascular endothelium, playing roles in cell-cell and cell-matrix interactions, extracellular matrix regulation, and neurodevelopment. The protein is involved in various cellular processes such as adhesion, proliferation, and apoptosis. In pathological conditions, SPOCK1 has been implicated in cancer progression, particularly in promoting epithelial-mesenchymal transition, invasion, and metastasis through activation of signaling pathways like PI3K/Akt and Wnt/β-catenin. Overexpression of SPOCK1 is associated with poor clinical outcomes in several cancer types.
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技术参数
- 靶点基因名
- SPOCK1
- 基因别名
- SPOCK; TIC1; TICN1
- 蛋白别名
- SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1; SPOCK1
- UniProt
- Q08629
- 物种
- Human
产品详情
- 靶点名称
- SPOCK1
- 蛋白名称
- SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
- 蛋白别名
- Testican-1; Protein SPOCK
- 靶点基因名
- SPOCK1
- 基因别名
- SPOCK; TIC1; TICN1
- UniProt
- Q08629
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 (SPOCK1) is a multidomain proteoglycan belonging to the SPARC family, consisting of an N-terminus, follistatin-like domain, extracellular calcium-binding domain, and a C-terminus with thyropin and Kazal-like domains. It contains both heparan and chondroitin sulfate chains, distinguishing it from SPOCK2 and SPOCK3. SPOCK1 is widely expressed in tissues including brain, cartilage, and vascular endothelium, playing roles in cell-cell and cell-matrix interactions, extracellular matrix regulation, and neurodevelopment. The protein is involved in various cellular processes such as adhesion, proliferation, and apoptosis. In pathological conditions, SPOCK1 has been implicated in cancer progression, particularly in promoting epithelial-mesenchymal transition, invasion, and metastasis through activation of signaling pathways like PI3K/Akt and Wnt/β-catenin. Overexpression of SPOCK1 is associated with poor clinical outcomes in several cancer types.