人 SPINK5 抗体对
01AB00594
Serine peptidase inhibitor Kazal type 5 (SPINK5), also known as lympho-epithelial Kazal-type-related inhibitor (LEKTI), is a protein that plays a crucial role in regulating serine peptidase activity in the skin and thymus. It is encoded by the SPINK5 gene located on chromosome 5q32. LEKTI is a large multidomain serine protease inhibitor consisting of 15 domains, which are cleaved into smaller functional fragments by the protease furin. It is primarily involved in the regulation of desquamation by selectively inhibiting KLK5, KLK7, and KLK14 in the epidermis. Mutations in the SPINK5 gene lead to Netherton syndrome, a disorder characterized by skin and hair abnormalities, and a high risk of allergies, asthma, and eczema due to the loss of LEKTI function and subsequent overactivity of serine peptidases. Additionally, normal variations in the SPINK5 gene have been associated with an increased risk of atopy, leading to disorders such as allergies, eczema, and asthma.
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技术参数
- 靶点基因名
- SPINK5
- 蛋白别名
- serine peptidase inhibitor Kazal type 5; SPINK5
- UniProt
- Q9NQ38
- 物种
- Human
产品详情
- 靶点名称
- SPINK5
- 蛋白名称
- serine peptidase inhibitor Kazal type 5
- 蛋白别名
- Serine protease inhibitor Kazal-type 5; Lympho-epithelial Kazal-type-related inhibitor; LEKTI) [Cleaved into: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665]
- 靶点基因名
- SPINK5
- UniProt
- Q9NQ38
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Serine peptidase inhibitor Kazal type 5 (SPINK5), also known as lympho-epithelial Kazal-type-related inhibitor (LEKTI), is a protein that plays a crucial role in regulating serine peptidase activity in the skin and thymus. It is encoded by the SPINK5 gene located on chromosome 5q32. LEKTI is a large multidomain serine protease inhibitor consisting of 15 domains, which are cleaved into smaller functional fragments by the protease furin. It is primarily involved in the regulation of desquamation by selectively inhibiting KLK5, KLK7, and KLK14 in the epidermis. Mutations in the SPINK5 gene lead to Netherton syndrome, a disorder characterized by skin and hair abnormalities, and a high risk of allergies, asthma, and eczema due to the loss of LEKTI function and subsequent overactivity of serine peptidases. Additionally, normal variations in the SPINK5 gene have been associated with an increased risk of atopy, leading to disorders such as allergies, eczema, and asthma.