人 SPINK1 抗体对
01AB00414
Serine peptidase inhibitor Kazal type 1 (SPINK1) is a secreted protein that functions as a protease inhibitor, primarily targeting trypsin. It contains 79 amino acids, including a 23-amino acid signal peptide, and features three intramolecular disulfide bridges. SPINK1 is mainly expressed in the pancreas, where it prevents premature activation of digestive enzymes. It also exhibits growth factor-like properties, binding to the epidermal growth factor receptor (EGFR) and activating downstream signaling pathways. SPINK1 plays roles in regulating autophagy and cellular proliferation. Mutations in the SPINK1 gene are associated with chronic pancreatitis and hereditary pancreatitis. Additionally, SPINK1 overexpression has been linked to various cancers, including pancreatic, ovarian, and prostate cancer, where it promotes tumor growth, metastasis, and drug resistance.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- SPINK1
- 基因别名
- PSTI
- 蛋白别名
- serine peptidase inhibitor Kazal type 1; SPINK1
- UniProt
- P00995
- 物种
- Human
产品详情
- 靶点名称
- SPINK1
- 蛋白名称
- serine peptidase inhibitor Kazal type 1
- 蛋白别名
- Serine protease inhibitor Kazal-type 1; Pancreatic secretory trypsin inhibitor; Tumor-associated trypsin inhibitor; TATI
- 靶点基因名
- SPINK1
- 基因别名
- PSTI
- UniProt
- P00995
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Serine peptidase inhibitor Kazal type 1 (SPINK1) is a secreted protein that functions as a protease inhibitor, primarily targeting trypsin. It contains 79 amino acids, including a 23-amino acid signal peptide, and features three intramolecular disulfide bridges. SPINK1 is mainly expressed in the pancreas, where it prevents premature activation of digestive enzymes. It also exhibits growth factor-like properties, binding to the epidermal growth factor receptor (EGFR) and activating downstream signaling pathways. SPINK1 plays roles in regulating autophagy and cellular proliferation. Mutations in the SPINK1 gene are associated with chronic pancreatitis and hereditary pancreatitis. Additionally, SPINK1 overexpression has been linked to various cancers, including pancreatic, ovarian, and prostate cancer, where it promotes tumor growth, metastasis, and drug resistance.