抗人 SPEF2 抗体对
01AB00950
Sperm flagellar 2 (SPEF2), encoded by the SPEF2 gene, is a 128 kDa protein comprising 1135 amino acids, critical for ciliogenesis and sperm flagellum assembly. It contains an N-terminal domain, coiled-coil regions, and a dynein heavy chain domain, facilitating its role in microtubule organization and dynein arm complex formation within motile cilia and sperm flagella. SPEF2 localizes to the sperm flagellum and ciliary axonemes, where it regulates microtubule sliding and motility. It interacts with components like IFT20 and DNAH1, essential for intraflagellar transport and structural integrity. SPEF2 is predominantly expressed in testis and ciliated tissues, underscoring its reproductive and respiratory functions. Mutations in SPEF2 are linked to primary ciliary dyskinesia 43 (CILD43), characterized by chronic respiratory infections, situs inversus, and male infertility due to impaired sperm motility (spermatogenic failure 20, SPGF20).
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技术参数
- 靶点基因名
- SPEF2
- 基因别名
- KIAA1770; KPL2
- 蛋白别名
- sperm flagellar 2; SPEF2
- UniProt
- Q9C093
- 物种
- Human
产品详情
- 靶点名称
- SPEF2
- 蛋白名称
- sperm flagellar 2
- 蛋白别名
- Sperm flagellar protein 2; Protein KPL2
- 靶点基因名
- SPEF2
- 基因别名
- KIAA1770; KPL2
- UniProt
- Q9C093
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Sperm flagellar 2 (SPEF2), encoded by the SPEF2 gene, is a 128 kDa protein comprising 1135 amino acids, critical for ciliogenesis and sperm flagellum assembly. It contains an N-terminal domain, coiled-coil regions, and a dynein heavy chain domain, facilitating its role in microtubule organization and dynein arm complex formation within motile cilia and sperm flagella. SPEF2 localizes to the sperm flagellum and ciliary axonemes, where it regulates microtubule sliding and motility. It interacts with components like IFT20 and DNAH1, essential for intraflagellar transport and structural integrity. SPEF2 is predominantly expressed in testis and ciliated tissues, underscoring its reproductive and respiratory functions. Mutations in SPEF2 are linked to primary ciliary dyskinesia 43 (CILD43), characterized by chronic respiratory infections, situs inversus, and male infertility due to impaired sperm motility (spermatogenic failure 20, SPGF20).