人 SP7 抗体对
01AB02900
Sp7 transcription factor (SP7), also known as Osterix, is a bone-specific zinc-finger transcriptional activator essential for osteoblast differentiation and skeletal formation. It functions downstream of Runx2, binding GC-rich motifs or interacting with Dlx factors to regulate the expression of major bone matrix genes like COL1A1 and BGLAP. SP7 controls the commitment and maturation of the osteoblast lineage, maintaining cortical bone integrity. Pathogenic variants in SP7 cause skeletal dysplasias, including forms of osteogenesis imperfecta characterized by bone fragility. Furthermore, genetic variations in SP7 are associated with bone mineral density variability and osteoporosis susceptibility.
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技术参数
- 靶点基因名
- SP7
- 基因别名
- OSX
- 蛋白别名
- Sp7 transcription factor; SP7
- UniProt
- Q8TDD2
- 物种
- Human
产品详情
- 靶点名称
- SP7
- 蛋白名称
- Sp7 transcription factor
- 蛋白别名
- Transcription factor Sp7; Zinc finger protein osterix
- 靶点基因名
- SP7
- 基因别名
- OSX
- UniProt
- Q8TDD2
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Sp7 transcription factor (SP7), also known as Osterix, is a bone-specific zinc-finger transcriptional activator essential for osteoblast differentiation and skeletal formation. It functions downstream of Runx2, binding GC-rich motifs or interacting with Dlx factors to regulate the expression of major bone matrix genes like COL1A1 and BGLAP. SP7 controls the commitment and maturation of the osteoblast lineage, maintaining cortical bone integrity. Pathogenic variants in SP7 cause skeletal dysplasias, including forms of osteogenesis imperfecta characterized by bone fragility. Furthermore, genetic variations in SP7 are associated with bone mineral density variability and osteoporosis susceptibility.