抗人 SP3 抗体对
01AB03906
Transcription factor Sp3 (SP3) is a member of the Sp family of transcription factors, characterized by its ability to bind to GC-rich promoter regions and regulate gene expression. SP3 contains multiple zinc finger domains that facilitate its interaction with DNA and other proteins, enabling it to either activate or repress target genes depending on the cellular context. This bifunctional nature allows SP3 to play a crucial role in various biological processes, including cell differentiation, proliferation, and apoptosis. Dysregulation of SP3 expression or function has been implicated in several diseases. For instance, altered levels of SP3 have been associated with tumor progression in breast and colorectal cancers, where it may influence the expression of oncogenes and tumor suppressor genes. Additionally, SP3's interactions with other transcription factors and co-regulators can affect inflammatory responses and metabolic pathways.
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技术参数
- 靶点基因名
- SP3
- 蛋白别名
- Sp3 transcription factor; SP3
- UniProt
- Q02447
- 物种
- Human
产品详情
- 靶点名称
- SP3
- 蛋白名称
- Sp3 transcription factor
- 蛋白别名
- Transcription factor Sp3; SPR-2
- 靶点基因名
- SP3
- UniProt
- Q02447
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Transcription factor Sp3 (SP3) is a member of the Sp family of transcription factors, characterized by its ability to bind to GC-rich promoter regions and regulate gene expression. SP3 contains multiple zinc finger domains that facilitate its interaction with DNA and other proteins, enabling it to either activate or repress target genes depending on the cellular context. This bifunctional nature allows SP3 to play a crucial role in various biological processes, including cell differentiation, proliferation, and apoptosis. Dysregulation of SP3 expression or function has been implicated in several diseases. For instance, altered levels of SP3 have been associated with tumor progression in breast and colorectal cancers, where it may influence the expression of oncogenes and tumor suppressor genes. Additionally, SP3's interactions with other transcription factors and co-regulators can affect inflammatory responses and metabolic pathways.