人 SORCS1 抗体对
01AB00410
Sortilin related VPS10 domain containing receptor 1 (SORCS1) is a critical protein involved in neuronal function and synaptic organization, particularly through its role in the trafficking of neurexin (Nrxn), a presynaptic adhesion molecule. SORCS1 facilitates the sorting of internalized Nrxn from early to recycling endosomes, which is essential for maintaining the balance of Nrxn surface levels between axons and dendrites. Dysregulation of SORCS1 has been linked to neurodegenerative diseases, especially Alzheimer's disease, where it may influence amyloid-beta interactions that disrupt synaptic integrity. Furthermore, genetic variations in SORCS1 have been associated with increased risk for neuropsychiatric disorders, underscoring its importance in brain health and disease mechanisms.
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技术参数
- 靶点基因名
- SORCS1
- 基因别名
- SORCS
- 蛋白别名
- sortilin related VPS10 domain containing receptor 1; SORCS1
- UniProt
- Q8WY21
- 物种
- Human
产品详情
- 靶点名称
- SORCS1
- 蛋白名称
- sortilin related VPS10 domain containing receptor 1
- 蛋白别名
- VPS10 domain-containing receptor SorCS1; hSorCS
- 靶点基因名
- SORCS1
- 基因别名
- SORCS
- UniProt
- Q8WY21
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Sortilin related VPS10 domain containing receptor 1 (SORCS1) is a critical protein involved in neuronal function and synaptic organization, particularly through its role in the trafficking of neurexin (Nrxn), a presynaptic adhesion molecule. SORCS1 facilitates the sorting of internalized Nrxn from early to recycling endosomes, which is essential for maintaining the balance of Nrxn surface levels between axons and dendrites. Dysregulation of SORCS1 has been linked to neurodegenerative diseases, especially Alzheimer's disease, where it may influence amyloid-beta interactions that disrupt synaptic integrity. Furthermore, genetic variations in SORCS1 have been associated with increased risk for neuropsychiatric disorders, underscoring its importance in brain health and disease mechanisms.