人生长抑素 28 抗体对
01AB03435
Somatostatin (Somatostatin 28) is a 28-amino acid cyclic peptide hormone derived from the proteolytic processing of preprosomatostatin. Primarily expressed in the enteroendocrine cells of the intestine and the nervous system, it functions as a potent neurotransmitter and neuromodulator. Somatostatin 28 exerts its biological effects by binding to five distinct G-protein-coupled receptor subtypes (SSTR1-5), although it generally exhibits a different affinity profile compared to the shorter somatostatin-14 isoform. Its primary physiological role involves the systemic inhibition of various hormones, including growth hormone, insulin, glucagon, gastrin, and IGF-1, thereby regulating metabolic homeostasis and gastrointestinal function. The specific conformational organization of its N-terminal segment is essential for its proper enzymatic generation and stability. Due to its rapid clearance and broad inhibitory profile, synthetic analogs of somatostatin have been extensively developed for clinical use in managing hormonal imbalances and certain neuroendocrine tumors.
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技术参数
- 靶点基因名
- SST
- 蛋白别名
- somatostatin; Somatostatin 28
- UniProt
- P61278
- 物种
- Human
产品详情
- 靶点名称
- Somatostatin 28
- 蛋白名称
- somatostatin
- 蛋白别名
- Somatostatin; Growth hormone release-inhibiting factor) [Cleaved into: Somatostatin-28; Somatostatin-14; SST-14); Neuronostatin; NST]
- 靶点基因名
- SST
- UniProt
- P61278
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Somatostatin (Somatostatin 28) is a 28-amino acid cyclic peptide hormone derived from the proteolytic processing of preprosomatostatin. Primarily expressed in the enteroendocrine cells of the intestine and the nervous system, it functions as a potent neurotransmitter and neuromodulator. Somatostatin 28 exerts its biological effects by binding to five distinct G-protein-coupled receptor subtypes (SSTR1-5), although it generally exhibits a different affinity profile compared to the shorter somatostatin-14 isoform. Its primary physiological role involves the systemic inhibition of various hormones, including growth hormone, insulin, glucagon, gastrin, and IGF-1, thereby regulating metabolic homeostasis and gastrointestinal function. The specific conformational organization of its N-terminal segment is essential for its proper enzymatic generation and stability. Due to its rapid clearance and broad inhibitory profile, synthetic analogs of somatostatin have been extensively developed for clinical use in managing hormonal imbalances and certain neuroendocrine tumors.