抗人 SNX25 抗体对
01AB02035
Sorting nexin 25 (SNX25) is a phosphoinositide-binding protein belonging to the sorting nexin family that plays a key role in endosomal trafficking and receptor sorting. It contains a phox homology (PX) domain for binding phosphatidylinositol-3-phosphate, alongside a regulator of G-protein signaling (RGS) domain and PXA/PXC regions involved in lipid transfer. SNX25 localizes to intracellular membrane-bound organelles where it promotes the lysosomal degradation of type I TGF-β receptors, thereby acting as a negative regulator of TGF-β signaling. Genetically, SNX25 is associated with neurodevelopmental and neurodegenerative phenotypes, including autosomal recessive spinocerebellar ataxia 20 and autosomal dominant intellectual developmental disorder 38, suggesting that impaired endosomal trafficking contributes to these conditions.
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技术参数
- 靶点基因名
- SNX25
- 蛋白别名
- sorting nexin 25; SNX25
- UniProt
- Q9H3E2
- 物种
- Human
产品详情
- 靶点名称
- SNX25
- 蛋白名称
- sorting nexin 25
- 蛋白别名
- Sorting nexin-25
- 靶点基因名
- SNX25
- UniProt
- Q9H3E2
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Sorting nexin 25 (SNX25) is a phosphoinositide-binding protein belonging to the sorting nexin family that plays a key role in endosomal trafficking and receptor sorting. It contains a phox homology (PX) domain for binding phosphatidylinositol-3-phosphate, alongside a regulator of G-protein signaling (RGS) domain and PXA/PXC regions involved in lipid transfer. SNX25 localizes to intracellular membrane-bound organelles where it promotes the lysosomal degradation of type I TGF-β receptors, thereby acting as a negative regulator of TGF-β signaling. Genetically, SNX25 is associated with neurodevelopmental and neurodegenerative phenotypes, including autosomal recessive spinocerebellar ataxia 20 and autosomal dominant intellectual developmental disorder 38, suggesting that impaired endosomal trafficking contributes to these conditions.