人 SNX21 抗体对
01AB01846
Sorting nexin family member 21 (SNX21) is a cytosolic and endosome-associated protein belonging to the sorting nexin family. It is characterized by a conserved N-terminal phox (PX) domain that binds phosphoinositides, facilitating its association with endosomal membranes. SNX21 also contains C-terminal tetratricopeptide repeat (TPR) motifs that serve as scaffolds for protein-protein interactions. A key functional partner is the Huntington’s disease protein, huntingtin (HTT), which SNX21 recruits to endosomes to influence endosomal organization and cargo trafficking. As a member of the PX-associated B subfamily, SNX21 participates in endosomal sorting and the maintenance of protein homeostasis. While it lacks a BAR domain, its role in scaffolding endosomal components suggests it is a critical regulator of neuronal endosomal dynamics and intracellular protein trafficking.
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技术参数
- 靶点基因名
- SNX21
- 基因别名
- C20orf161; SNXL
- 蛋白别名
- sorting nexin family member 21; SNX21
- UniProt
- Q969T3
- 物种
- Human
产品详情
- 靶点名称
- SNX21
- 蛋白名称
- sorting nexin family member 21
- 蛋白别名
- Sorting nexin-21; Sorting nexin L; SNX-L
- 靶点基因名
- SNX21
- 基因别名
- C20orf161; SNXL
- UniProt
- Q969T3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Sorting nexin family member 21 (SNX21) is a cytosolic and endosome-associated protein belonging to the sorting nexin family. It is characterized by a conserved N-terminal phox (PX) domain that binds phosphoinositides, facilitating its association with endosomal membranes. SNX21 also contains C-terminal tetratricopeptide repeat (TPR) motifs that serve as scaffolds for protein-protein interactions. A key functional partner is the Huntington’s disease protein, huntingtin (HTT), which SNX21 recruits to endosomes to influence endosomal organization and cargo trafficking. As a member of the PX-associated B subfamily, SNX21 participates in endosomal sorting and the maintenance of protein homeostasis. While it lacks a BAR domain, its role in scaffolding endosomal components suggests it is a critical regulator of neuronal endosomal dynamics and intracellular protein trafficking.