人 SNRPF 抗体对
01AB02898
Small nuclear ribonucleoprotein polypeptide F (SNRPF) is a core Sm protein that serves as an essential component of the spliceosomal small nuclear ribonucleoproteins (snRNPs), including U1, U2, U4, U5, and the minor U12 complexes. It plays a fundamental role in pre-mRNA splicing by enabling RNA binding and participating in the assembly of the spliceosome within the methylosome. SNRPF is also a component of the U7 snRNP, which is required for the 3'-end processing of histone mRNA. It localizes to both the cytosol and the nucleus, interacting with proteins such as DDX20 and other Sm polypeptides to facilitate RNA processing. Clinically, SNRPF is highly relevant to spinal muscular atrophy (SMA), a severe neurodegenerative disorder characterized by the loss of motor neurons and progressive muscle wasting. Furthermore, it has been identified as a significant biomarker in nasopharynx carcinoma, reflecting its critical involvement in the RNA metabolism pathways that are often disrupted in neuromuscular and oncological diseases.
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技术参数
- 靶点基因名
- SNRPF
- 基因别名
- PBSCF
- 蛋白别名
- small nuclear ribonucleoprotein polypeptide F; SNRPF
- UniProt
- P62306
- 物种
- Human
产品详情
- 靶点名称
- SNRPF
- 蛋白名称
- small nuclear ribonucleoprotein polypeptide F
- 蛋白别名
- Small nuclear ribonucleoprotein F; snRNP-F; Sm protein F; Sm-F; SmF
- 靶点基因名
- SNRPF
- 基因别名
- PBSCF
- UniProt
- P62306
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Small nuclear ribonucleoprotein polypeptide F (SNRPF) is a core Sm protein that serves as an essential component of the spliceosomal small nuclear ribonucleoproteins (snRNPs), including U1, U2, U4, U5, and the minor U12 complexes. It plays a fundamental role in pre-mRNA splicing by enabling RNA binding and participating in the assembly of the spliceosome within the methylosome. SNRPF is also a component of the U7 snRNP, which is required for the 3'-end processing of histone mRNA. It localizes to both the cytosol and the nucleus, interacting with proteins such as DDX20 and other Sm polypeptides to facilitate RNA processing. Clinically, SNRPF is highly relevant to spinal muscular atrophy (SMA), a severe neurodegenerative disorder characterized by the loss of motor neurons and progressive muscle wasting. Furthermore, it has been identified as a significant biomarker in nasopharynx carcinoma, reflecting its critical involvement in the RNA metabolism pathways that are often disrupted in neuromuscular and oncological diseases.