抗人 SMPD3 抗体对
01AB01594
Sphingomyelin phosphodiesterase 3 (SMPD3), also known as neutral sphingomyelinase 2, is an enzyme encoded by the SMPD3 gene in humans. This protein plays a critical role in sphingolipid metabolism by catalyzing the hydrolysis of sphingomyelin to generate ceramide and phosphocholine, a process pivotal for regulating cellular functions such as apoptosis, cell cycle arrest, and growth control. SMPD3 is involved in several metabolic pathways, including ceramide signaling, glycosphingolipid metabolism, and lipid and lipoprotein metabolism, highlighting its importance in maintaining cellular lipid homeostasis. Structurally, SMPD3 shares a conserved catalytic domain with other sphingomyelinases, and its activity is essential for multicellular organism development and the positive regulation of ceramide biosynthesis. Dysregulation or mutations in SMPD3 have been associated with pathological conditions such as necrosis and may contribute to broader metabolic or developmental disorders.
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技术参数
- 靶点基因名
- SMPD3
- 蛋白别名
- sphingomyelin phosphodiesterase 3; SMPD3
- UniProt
- Q9NY59
- 物种
- Human
产品详情
- 靶点名称
- SMPD3
- 蛋白名称
- sphingomyelin phosphodiesterase 3
- 蛋白别名
- Sphingomyelin phosphodiesterase 3; Neutral sphingomyelinase 2; nSMase-2; nSMase2; Neutral sphingomyelinase II
- 靶点基因名
- SMPD3
- UniProt
- Q9NY59
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Sphingomyelin phosphodiesterase 3 (SMPD3), also known as neutral sphingomyelinase 2, is an enzyme encoded by the SMPD3 gene in humans. This protein plays a critical role in sphingolipid metabolism by catalyzing the hydrolysis of sphingomyelin to generate ceramide and phosphocholine, a process pivotal for regulating cellular functions such as apoptosis, cell cycle arrest, and growth control. SMPD3 is involved in several metabolic pathways, including ceramide signaling, glycosphingolipid metabolism, and lipid and lipoprotein metabolism, highlighting its importance in maintaining cellular lipid homeostasis. Structurally, SMPD3 shares a conserved catalytic domain with other sphingomyelinases, and its activity is essential for multicellular organism development and the positive regulation of ceramide biosynthesis. Dysregulation or mutations in SMPD3 have been associated with pathological conditions such as necrosis and may contribute to broader metabolic or developmental disorders.