人 SMOC1 抗体对
01AB02578
SPARC related modular calcium binding 1 (SMOC1) is a secreted modular calcium-binding protein localized to basement membranes and the extracellular matrix. It contains multiple structural domains, including follistatin-like and thyroglobulin-like domains, which facilitate its interaction with various growth factors essential for skeletal formation, limb patterning, and ocular development. SMOC1 functions as an antagonist of ALK5, thereby modulating TGF-β signaling pathways to regulate endothelial cell proliferation, angiogenesis, and tissue fibrosis. Beyond its developmental roles, SMOC1 acts as a glucose-responsive hepatokine involved in metabolic regulation. Clinical relevance is well-established in developmental disorders, where mutations in the SMOC1 gene are a known cause of microphthalmia and limb anomalies. Additionally, its upregulation is observed in several malignancies, including gliomas and hepatocellular carcinoma, suggesting a role in tumor progression and vascular remodeling.
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技术参数
- 靶点基因名
- SMOC1
- 蛋白别名
- SPARC related modular calcium binding 1; SMOC1
- UniProt
- Q9H4F8
- 物种
- Human
产品详情
- 靶点名称
- SMOC1
- 蛋白名称
- SPARC related modular calcium binding 1
- 蛋白别名
- SPARC-related modular calcium-binding protein 1; Secreted modular calcium-binding protein 1; SMOC-1
- 靶点基因名
- SMOC1
- UniProt
- Q9H4F8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
SPARC related modular calcium binding 1 (SMOC1) is a secreted modular calcium-binding protein localized to basement membranes and the extracellular matrix. It contains multiple structural domains, including follistatin-like and thyroglobulin-like domains, which facilitate its interaction with various growth factors essential for skeletal formation, limb patterning, and ocular development. SMOC1 functions as an antagonist of ALK5, thereby modulating TGF-β signaling pathways to regulate endothelial cell proliferation, angiogenesis, and tissue fibrosis. Beyond its developmental roles, SMOC1 acts as a glucose-responsive hepatokine involved in metabolic regulation. Clinical relevance is well-established in developmental disorders, where mutations in the SMOC1 gene are a known cause of microphthalmia and limb anomalies. Additionally, its upregulation is observed in several malignancies, including gliomas and hepatocellular carcinoma, suggesting a role in tumor progression and vascular remodeling.