人 SLURP1 抗体对
01AB01829
SLURP1 (Secreted Ly6/uPAR-related protein 1) is an immunomodulatory protein that plays important roles in skin development, inflammation regulation, and cancer suppression. It acts primarily by binding to nicotinic acetylcholine receptors, especially α7-nAChR, as well as other receptors like EGFR and PDGFRα. SLURP1 inhibits neutrophil adhesion and migration, suppresses pro-inflammatory cytokine production, and modulates keratinocyte differentiation. Mutations in the SLURP1 gene cause Mal de Meleda, a rare autosomal recessive skin disorder characterized by palmoplantar keratoderma. In cancer, SLURP1 demonstrates antiproliferative and anti-migration effects on lung adenocarcinoma cells by downregulating the PI3K/AKT/mTOR signaling pathway. Additionally, SLURP1 has been shown to prevent inflammation-induced proliferation in intestinal epithelial cells by modulating NF-κB expression and reversing LPS-induced inflammatory responses.
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技术参数
- 靶点基因名
- SLURP1
- 基因别名
- ARS
- 蛋白别名
- secreted LY6/PLAUR domain containing 1; SLURP1
- UniProt
- P55000
- 物种
- Human
产品详情
- 靶点名称
- SLURP1
- 蛋白名称
- secreted LY6/PLAUR domain containing 1
- 蛋白别名
- Secreted Ly-6/uPAR-related protein 1; SLURP-1; ARS component B; ARS(component B)-81/S; Anti-neoplastic urinary protein; ANUP
- 靶点基因名
- SLURP1
- 基因别名
- ARS
- UniProt
- P55000
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
SLURP1 (Secreted Ly6/uPAR-related protein 1) is an immunomodulatory protein that plays important roles in skin development, inflammation regulation, and cancer suppression. It acts primarily by binding to nicotinic acetylcholine receptors, especially α7-nAChR, as well as other receptors like EGFR and PDGFRα. SLURP1 inhibits neutrophil adhesion and migration, suppresses pro-inflammatory cytokine production, and modulates keratinocyte differentiation. Mutations in the SLURP1 gene cause Mal de Meleda, a rare autosomal recessive skin disorder characterized by palmoplantar keratoderma. In cancer, SLURP1 demonstrates antiproliferative and anti-migration effects on lung adenocarcinoma cells by downregulating the PI3K/AKT/mTOR signaling pathway. Additionally, SLURP1 has been shown to prevent inflammation-induced proliferation in intestinal epithelial cells by modulating NF-κB expression and reversing LPS-induced inflammatory responses.