人 SLITRK6 抗体对
01AB00404
SLIT and NTRK like family member 6 (SLITRK6) is a neuronal transmembrane protein encoded by the SLITRK6 gene, predominantly expressed in the central nervous system, retina, and inner ear. As part of the SLITRK family, it features leucine-rich repeat (LRR) domains in its extracellular region and shares homology with Slit proteins, known for axon guidance. Structurally, SLITRK6 is a type I membrane protein with an extracellular LRR domain, a transmembrane region, and a cytoplasmic tail potentially involved in intracellular signaling. It regulates neurite outgrowth, synaptic connectivity, and cell adhesion, crucial for sensory system development. Pathogenic mutations in SLITRK6 are linked to autosomal dominant nonsyndromic high myopia (MYP25), a severe form of nearsightedness, and hearing impairment, likely due to its role in retinal and cochlear circuit formation.
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技术参数
- 靶点基因名
- SLITRK6
- 蛋白别名
- SLIT and NTRK like family member 6; SLITRK6
- UniProt
- Q9H5Y7
- 物种
- Human
产品详情
- 靶点名称
- SLITRK6
- 蛋白名称
- SLIT and NTRK like family member 6
- 蛋白别名
- SLIT and NTRK-like protein 6
- 靶点基因名
- SLITRK6
- UniProt
- Q9H5Y7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
SLIT and NTRK like family member 6 (SLITRK6) is a neuronal transmembrane protein encoded by the SLITRK6 gene, predominantly expressed in the central nervous system, retina, and inner ear. As part of the SLITRK family, it features leucine-rich repeat (LRR) domains in its extracellular region and shares homology with Slit proteins, known for axon guidance. Structurally, SLITRK6 is a type I membrane protein with an extracellular LRR domain, a transmembrane region, and a cytoplasmic tail potentially involved in intracellular signaling. It regulates neurite outgrowth, synaptic connectivity, and cell adhesion, crucial for sensory system development. Pathogenic mutations in SLITRK6 are linked to autosomal dominant nonsyndromic high myopia (MYP25), a severe form of nearsightedness, and hearing impairment, likely due to its role in retinal and cochlear circuit formation.