人 SLC9A9 抗体对
01AB00945
Solute carrier family 9 member A9 (SLC9A9), also known as sodium/hydrogen exchanger 9 (NHE9), is a membrane protein that regulates the luminal pH of recycling endosomes. It facilitates proton efflux, counteracting the acidity generated by vacuolar ATPase and limiting luminal acidification. SLC9A9 plays a crucial role in maintaining cation homeostasis and is involved in various cellular processes, including endosomal trafficking and signaling. The protein is expressed in multiple tissues, with high levels observed in the brain. Mutations in the SLC9A9 gene have been associated with several neuropsychiatric disorders, including autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD), and epilepsy. Additionally, alterations in SLC9A9 expression and function have been linked to various cancers, such as glioblastoma and esophageal squamous cell carcinoma.
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技术参数
- 靶点基因名
- SLC9A9
- 基因别名
- NHE9
- 蛋白别名
- solute carrier family 9 member A9; SLC9A9
- UniProt
- Q8IVB4
- 物种
- Human
产品详情
- 靶点名称
- SLC9A9
- 蛋白名称
- solute carrier family 9 member A9
- 蛋白别名
- Sodium/hydrogen exchanger 9; Na(+)/H(+) exchanger 9; NHE-9; Solute carrier family 9 member 9
- 靶点基因名
- SLC9A9
- 基因别名
- NHE9
- UniProt
- Q8IVB4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Solute carrier family 9 member A9 (SLC9A9), also known as sodium/hydrogen exchanger 9 (NHE9), is a membrane protein that regulates the luminal pH of recycling endosomes. It facilitates proton efflux, counteracting the acidity generated by vacuolar ATPase and limiting luminal acidification. SLC9A9 plays a crucial role in maintaining cation homeostasis and is involved in various cellular processes, including endosomal trafficking and signaling. The protein is expressed in multiple tissues, with high levels observed in the brain. Mutations in the SLC9A9 gene have been associated with several neuropsychiatric disorders, including autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD), and epilepsy. Additionally, alterations in SLC9A9 expression and function have been linked to various cancers, such as glioblastoma and esophageal squamous cell carcinoma.