人 SLAMF1 抗体对
01AB01837
Signaling lymphocytic activation molecule family member 1 (SLAMF1) is a type I transmembrane receptor of the immunoglobulin superfamily, expressed on various hematopoietic cells including T and B lymphocytes, NK cells, and macrophages. It contains extracellular Ig-like domains and cytoplasmic immunoreceptor tyrosine switch motifs that recruit SH2-domain adaptors, such as SAP and EAT-2, to modulate downstream signaling through Fyn, ERK, and NF-κB. SLAMF1 acts as a self-ligand to mediate T–B cell collaboration and regulate cytokine production and phagosome maturation. It also contributes to innate immunity by sensing outer-membrane proteins of Gram-negative bacteria. Clinically, SLAMF1 serves as the primary entry receptor for the measles virus. Mutations in its signaling pathway, particularly involving the adaptor SAP, are linked to X-linked lymphoproliferative disease. It is also implicated in autoimmune thyroid disease and certain cancers, where it modulates tumor growth and immunity.
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技术参数
- 靶点基因名
- SLAMF1
- 基因别名
- SLAM
- 蛋白别名
- signaling lymphocytic activation molecule family member 1; SLAMF1
- UniProt
- Q13291
- 物种
- Human
产品详情
- 靶点名称
- SLAMF1
- 蛋白名称
- signaling lymphocytic activation molecule family member 1
- 蛋白别名
- Signaling lymphocytic activation molecule; CDw150; IPO-3; SLAM family member 1; CD antigen CD150
- 靶点基因名
- SLAMF1
- 基因别名
- SLAM
- UniProt
- Q13291
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Signaling lymphocytic activation molecule family member 1 (SLAMF1) is a type I transmembrane receptor of the immunoglobulin superfamily, expressed on various hematopoietic cells including T and B lymphocytes, NK cells, and macrophages. It contains extracellular Ig-like domains and cytoplasmic immunoreceptor tyrosine switch motifs that recruit SH2-domain adaptors, such as SAP and EAT-2, to modulate downstream signaling through Fyn, ERK, and NF-κB. SLAMF1 acts as a self-ligand to mediate T–B cell collaboration and regulate cytokine production and phagosome maturation. It also contributes to innate immunity by sensing outer-membrane proteins of Gram-negative bacteria. Clinically, SLAMF1 serves as the primary entry receptor for the measles virus. Mutations in its signaling pathway, particularly involving the adaptor SAP, are linked to X-linked lymphoproliferative disease. It is also implicated in autoimmune thyroid disease and certain cancers, where it modulates tumor growth and immunity.