人 SIRT1 抗体对
01AB04149
Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase that plays a crucial role in regulating various cellular processes, including metabolism, stress response, and longevity. This protein is encoded by the SIRT1 gene and is primarily located in the nucleus, where it deacetylates transcription factors involved in cellular regulation. Functionally, SIRT1 interacts with a wide range of proteins, modulating their activity through deacetylation, which affects chromatin structure and transcriptional regulation. Additionally, SIRT1's involvement in mitochondrial biogenesis and lipid metabolism highlights its importance in maintaining cellular homeostasis. SIRT1 has been implicated in numerous diseases, including diabetes, cancer, obesity, inflammation, neurodegenerative disorders, and cardiovascular diseases, primarily due to its influence on metabolic pathways and gene expression. The dysregulation of SIRT1 activity can lead to increased insulin resistance and chronic inflammation, contributing to the pathogenesis of these conditions.
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技术参数
- 靶点基因名
- SIRT1
- 基因别名
- SIR2L1
- 蛋白别名
- sirtuin 1; SIRT1
- UniProt
- Q96EB6
- 物种
- Human
产品详情
- 靶点名称
- SIRT1
- 蛋白名称
- sirtuin 1
- 蛋白别名
- NAD-dependent protein deacetylase sirtuin-1; hSIRT1; NAD-dependent protein deacylase sirtuin-1; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2) [Cleaved into: SirtT1 75 kDa fragment; 75SirT1]
- 靶点基因名
- SIRT1
- 基因别名
- SIR2L1
- UniProt
- Q96EB6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase that plays a crucial role in regulating various cellular processes, including metabolism, stress response, and longevity. This protein is encoded by the SIRT1 gene and is primarily located in the nucleus, where it deacetylates transcription factors involved in cellular regulation. Functionally, SIRT1 interacts with a wide range of proteins, modulating their activity through deacetylation, which affects chromatin structure and transcriptional regulation. Additionally, SIRT1's involvement in mitochondrial biogenesis and lipid metabolism highlights its importance in maintaining cellular homeostasis. SIRT1 has been implicated in numerous diseases, including diabetes, cancer, obesity, inflammation, neurodegenerative disorders, and cardiovascular diseases, primarily due to its influence on metabolic pathways and gene expression. The dysregulation of SIRT1 activity can lead to increased insulin resistance and chronic inflammation, contributing to the pathogenesis of these conditions.