抗人 SIRPG 抗体对
01AB00940
Signal regulatory protein gamma (SIRPG) is a member of the signal regulatory protein (SIRP) family, which plays a role in immune cell signaling and adhesion. Encoded by the SIRPG gene, SIRPG is predominantly expressed on immune cells such as T cells and dendritic cells. Structurally, it contains extracellular immunoglobulin-like domains that mediate interactions with CD47, a ligand involved in cell-cell communication and immune regulation. Unlike other SIRP family members, SIRPG lacks significant intracellular signaling motifs, suggesting its primary role is in adhesion rather than signal transduction. The interaction between SIRPG and CD47 facilitates T-cell activation and dendritic cell function, contributing to immune surveillance. Mutations or dysregulation of SIRPG have been associated with impaired immune responses, potentially affecting conditions such as cancer or autoimmune diseases.
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技术参数
- 靶点基因名
- SIRPG
- 基因别名
- SIRPB2
- 蛋白别名
- signal regulatory protein gamma; SIRPG
- UniProt
- Q9P1W8
- 物种
- Human
产品详情
- 靶点名称
- SIRPG
- 蛋白名称
- signal regulatory protein gamma
- 蛋白别名
- Signal-regulatory protein gamma; SIRP-gamma; CD172 antigen-like family member B; Signal-regulatory protein beta-2; SIRP-b2; SIRP-beta-2; CD antigen CD172g
- 靶点基因名
- SIRPG
- 基因别名
- SIRPB2
- UniProt
- Q9P1W8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Signal regulatory protein gamma (SIRPG) is a member of the signal regulatory protein (SIRP) family, which plays a role in immune cell signaling and adhesion. Encoded by the SIRPG gene, SIRPG is predominantly expressed on immune cells such as T cells and dendritic cells. Structurally, it contains extracellular immunoglobulin-like domains that mediate interactions with CD47, a ligand involved in cell-cell communication and immune regulation. Unlike other SIRP family members, SIRPG lacks significant intracellular signaling motifs, suggesting its primary role is in adhesion rather than signal transduction. The interaction between SIRPG and CD47 facilitates T-cell activation and dendritic cell function, contributing to immune surveillance. Mutations or dysregulation of SIRPG have been associated with impaired immune responses, potentially affecting conditions such as cancer or autoimmune diseases.