抗人 SIGLEC9 抗体对
01AB01353
Sialic acid binding Ig like lectin 9 (SIGLEC9) is a transmembrane protein belonging to the immunoglobulin superfamily, characterized by an N-terminal Ig-like V-type domain responsible for sialic acid binding, followed by two Ig-like C2-type domains, a transmembrane region, and a cytoplasmic tail. The protein consists of 463 amino acids and is predominantly expressed on neutrophils, monocytes, a subset of NK cells, B cells, and some CD8+ T cells. SIGLEC9 mediates sialic acid-dependent cell adhesion, binding preferentially and equally to both α2,3- and α2,6-linked sialic acids, and is closely related to SIGLEC7, sharing about 80% sequence identity. Functionally, it is involved in cell-cell interactions and immune modulation through its carbohydrate-binding activity. Clinically, SIGLEC9 has been implicated in immune regulation and is associated with inflammatory and autoimmune diseases, as its expression and function can influence immune cell signaling and inflammatory responses.
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技术参数
- 靶点基因名
- SIGLEC9
- 蛋白别名
- sialic acid binding Ig like lectin 9; SIGLEC9
- UniProt
- Q9Y336
- 物种
- Human
产品详情
- 靶点名称
- SIGLEC9
- 蛋白名称
- sialic acid binding Ig like lectin 9
- 蛋白别名
- Sialic acid-binding Ig-like lectin 9; Siglec-9; CDw329; Protein FOAP-9; CD antigen CD329
- 靶点基因名
- SIGLEC9
- UniProt
- Q9Y336
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Sialic acid binding Ig like lectin 9 (SIGLEC9) is a transmembrane protein belonging to the immunoglobulin superfamily, characterized by an N-terminal Ig-like V-type domain responsible for sialic acid binding, followed by two Ig-like C2-type domains, a transmembrane region, and a cytoplasmic tail. The protein consists of 463 amino acids and is predominantly expressed on neutrophils, monocytes, a subset of NK cells, B cells, and some CD8+ T cells. SIGLEC9 mediates sialic acid-dependent cell adhesion, binding preferentially and equally to both α2,3- and α2,6-linked sialic acids, and is closely related to SIGLEC7, sharing about 80% sequence identity. Functionally, it is involved in cell-cell interactions and immune modulation through its carbohydrate-binding activity. Clinically, SIGLEC9 has been implicated in immune regulation and is associated with inflammatory and autoimmune diseases, as its expression and function can influence immune cell signaling and inflammatory responses.