抗人 SIGLEC7 抗体对
01AB02426
Sialic acid-binding Ig-like lectin 7 (SIGLEC7) is a member of the Siglec family of proteins, primarily expressed on natural killer (NK) cells and some myeloid cells, where it plays a crucial role in immune regulation. SIGLEC7 recognizes sialylated glycoconjugates, facilitating cell-cell interactions and modulating immune responses. Its binding to sialic acid-containing ligands can inhibit immune activation, promoting immune tolerance and potentially contributing to tumor evasion. Dysregulation of SIGLEC7 has been implicated in various diseases, particularly in cancer, where its expression on tumor-infiltrating lymphocytes can lead to immune suppression, allowing tumors to grow unchecked. Additionally, elevated SIGLEC7 levels have been associated with chronic inflammatory conditions such as rheumatoid arthritis and multiple sclerosis.
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技术参数
- 靶点基因名
- SIGLEC7
- 基因别名
- AIRM1
- 蛋白别名
- sialic acid binding Ig like lectin 7; SIGLEC7
- UniProt
- Q9Y286
- 物种
- Human
产品详情
- 靶点名称
- SIGLEC7
- 蛋白名称
- sialic acid binding Ig like lectin 7
- 蛋白别名
- Sialic acid-binding Ig-like lectin 7; Siglec-7; Adhesion inhibitory receptor molecule 1; AIRM-1; CDw328; D-siglec; QA79 membrane protein; p75; CD antigen CD328
- 靶点基因名
- SIGLEC7
- 基因别名
- AIRM1
- UniProt
- Q9Y286
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Sialic acid-binding Ig-like lectin 7 (SIGLEC7) is a member of the Siglec family of proteins, primarily expressed on natural killer (NK) cells and some myeloid cells, where it plays a crucial role in immune regulation. SIGLEC7 recognizes sialylated glycoconjugates, facilitating cell-cell interactions and modulating immune responses. Its binding to sialic acid-containing ligands can inhibit immune activation, promoting immune tolerance and potentially contributing to tumor evasion. Dysregulation of SIGLEC7 has been implicated in various diseases, particularly in cancer, where its expression on tumor-infiltrating lymphocytes can lead to immune suppression, allowing tumors to grow unchecked. Additionally, elevated SIGLEC7 levels have been associated with chronic inflammatory conditions such as rheumatoid arthritis and multiple sclerosis.