人 SIGLEC1 抗体对
01AB00592
Sialic acid binding Ig like lectin 1 (SIGLEC1), also known as sialoadhesin and CD169, is a 175-185 kDa glycoprotein belonging to the immunoglobulin superfamily. It is a type I transmembrane protein expressed primarily by a subpopulation of macrophages and plays a crucial role in mediating cell-cell interactions through sialic acid-dependent binding to glycoconjugate ligands on cell surfaces. The protein contains an N-terminal Ig-like V-set domain and 16 Ig-like C2-set domains, which preferentially bind to alpha-2,3-linked sialic acid residues. SIGLEC1 is involved in various biological processes, including phagocytosis of sialylated bacteria and viruses, and it enhances macrophage-to-T-cell transmission of viruses such as HIV-1 and SARS-CoV-2. Diseases associated with SIGLEC1 include rheumatoid arthritis and heart block, and it has been implicated in systemic lupus erythematosus and idiopathic inflammatory myopathies.
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技术参数
- 靶点基因名
- SIGLEC1
- 基因别名
- SN
- 蛋白别名
- sialic acid binding Ig like lectin 1; SIGLEC1
- UniProt
- Q9BZZ2
- 物种
- Human
产品详情
- 靶点名称
- SIGLEC1
- 蛋白名称
- sialic acid binding Ig like lectin 1
- 蛋白别名
- Sialoadhesin; Sialic acid-binding Ig-like lectin 1; Siglec-1; CD antigen CD169
- 靶点基因名
- SIGLEC1
- 基因别名
- SN
- UniProt
- Q9BZZ2
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Sialic acid binding Ig like lectin 1 (SIGLEC1), also known as sialoadhesin and CD169, is a 175-185 kDa glycoprotein belonging to the immunoglobulin superfamily. It is a type I transmembrane protein expressed primarily by a subpopulation of macrophages and plays a crucial role in mediating cell-cell interactions through sialic acid-dependent binding to glycoconjugate ligands on cell surfaces. The protein contains an N-terminal Ig-like V-set domain and 16 Ig-like C2-set domains, which preferentially bind to alpha-2,3-linked sialic acid residues. SIGLEC1 is involved in various biological processes, including phagocytosis of sialylated bacteria and viruses, and it enhances macrophage-to-T-cell transmission of viruses such as HIV-1 and SARS-CoV-2. Diseases associated with SIGLEC1 include rheumatoid arthritis and heart block, and it has been implicated in systemic lupus erythematosus and idiopathic inflammatory myopathies.