人 SHOX 抗体对
01AB01348
SHOX homeobox (SHOX) is transcription factor critical for skeletal development, particularly in the arms and legs. It regulates cell proliferation and differentiation in bone progenitor cells, maintaining their undifferentiated state while suppressing early osteogenic gene expression. SHOX protein functions as both an activator and repressor of target genes and is expressed in diverse tissues, including human mesenchymal stem cells (hMSCs). Knockdown studies in zebrafish embryos and hMSCs reveal its essential role in bone growth, with deficiencies leading to reduced proliferation and premature differentiation of skeletal progenitors. Mutations or deletions of SHOX are linked to disorders like Léri-Weill dyschondrosteosis and Turner syndrome, characterized by short stature and skeletal abnormalities such as Madelung deformity. These conditions arise from disrupted SHOX activity, impairing normal bone development.
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技术参数
- 靶点基因名
- SHOX
- 基因别名
- PHOG
- 蛋白别名
- SHOX homeobox; SHOX
- UniProt
- O15266
- 物种
- Human
产品详情
- 靶点名称
- SHOX
- 蛋白名称
- SHOX homeobox
- 蛋白别名
- Short stature homeobox protein; Pseudoautosomal homeobox-containing osteogenic protein; Short stature homeobox-containing protein
- 靶点基因名
- SHOX
- 基因别名
- PHOG
- UniProt
- O15266
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
SHOX homeobox (SHOX) is transcription factor critical for skeletal development, particularly in the arms and legs. It regulates cell proliferation and differentiation in bone progenitor cells, maintaining their undifferentiated state while suppressing early osteogenic gene expression. SHOX protein functions as both an activator and repressor of target genes and is expressed in diverse tissues, including human mesenchymal stem cells (hMSCs). Knockdown studies in zebrafish embryos and hMSCs reveal its essential role in bone growth, with deficiencies leading to reduced proliferation and premature differentiation of skeletal progenitors. Mutations or deletions of SHOX are linked to disorders like Léri-Weill dyschondrosteosis and Turner syndrome, characterized by short stature and skeletal abnormalities such as Madelung deformity. These conditions arise from disrupted SHOX activity, impairing normal bone development.