人 SHCBP1L 抗体对
01AB03025
SHC binding and spindle associated 1 like (SHCBP1L) is a testis-enriched cytoplasmic protein that functions as a critical spindle-associated factor during meiosis. Predominantly expressed in pachytene spermatocytes and round spermatids, it localizes to meiotic spindles and works in conjunction with HSPA2 to maintain spindle integrity and ensure proper chromosome alignment during meiosis I. This activity is essential for supporting normal spermatogenesis and male germ cell development. Loss-of-function studies indicate that SHCBP1L deficiency leads to spindle instability, misaligned chromosomes, and the apoptosis of spermatocytes. Clinically, these defects result in severely impaired spermatogenesis and male infertility, while female fertility remains unaffected. SHCBP1L thus serves as a specialized regulator of the meiotic machinery necessary for male reproductive health.
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技术参数
- 靶点基因名
- SHCBP1L
- 基因别名
- C1orf14
- 蛋白别名
- SHC binding and spindle associated 1 like; SHCBP1L
- UniProt
- Q9BZQ2
- 物种
- Human
产品详情
- 靶点名称
- SHCBP1L
- 蛋白名称
- SHC binding and spindle associated 1 like
- 蛋白别名
- Testicular spindle-associated protein SHCBP1L; SHC SH2 domain-binding protein 1-like protein
- 靶点基因名
- SHCBP1L
- 基因别名
- C1orf14
- UniProt
- Q9BZQ2
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
SHC binding and spindle associated 1 like (SHCBP1L) is a testis-enriched cytoplasmic protein that functions as a critical spindle-associated factor during meiosis. Predominantly expressed in pachytene spermatocytes and round spermatids, it localizes to meiotic spindles and works in conjunction with HSPA2 to maintain spindle integrity and ensure proper chromosome alignment during meiosis I. This activity is essential for supporting normal spermatogenesis and male germ cell development. Loss-of-function studies indicate that SHCBP1L deficiency leads to spindle instability, misaligned chromosomes, and the apoptosis of spermatocytes. Clinically, these defects result in severely impaired spermatogenesis and male infertility, while female fertility remains unaffected. SHCBP1L thus serves as a specialized regulator of the meiotic machinery necessary for male reproductive health.