人 SH2D4A 抗体对
01AB02291
SH2 domain containing 4A (SH2D4A) is a cytosolic adaptor protein characterized by a central Src homology 2 (SH2) domain that selectively binds phosphotyrosine motifs. It functions as a negative regulator of signaling by competing with phospholipase C gamma (PLCG) for binding to estrogen receptor alpha (ESR1), thereby inhibiting downstream estrogen-responsive pathways. SH2D4A also facilitates the recruitment of phosphatases, such as protein phosphatase 1, to modulate phosphotyrosine networks and cytoskeletal dynamics. It plays a role in T-cell development and the regulation of cellular proliferation. Clinically, the downregulation of SH2D4A is implicated in the progression of estrogen-driven breast cancer and other hormone-dependent malignancies, where it acts as a putative tumor suppressor.
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技术参数
- 靶点基因名
- SH2D4A
- 基因别名
- PPP1R38; SH2A
- 蛋白别名
- SH2 domain containing 4A; SH2D4A
- UniProt
- Q9H788
- 物种
- Human
产品详情
- 靶点名称
- SH2D4A
- 蛋白名称
- SH2 domain containing 4A
- 蛋白别名
- SH2 domain-containing protein 4A; Protein SH(2)A; Protein phosphatase 1 regulatory subunit 38
- 靶点基因名
- SH2D4A
- 基因别名
- PPP1R38; SH2A
- UniProt
- Q9H788
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
SH2 domain containing 4A (SH2D4A) is a cytosolic adaptor protein characterized by a central Src homology 2 (SH2) domain that selectively binds phosphotyrosine motifs. It functions as a negative regulator of signaling by competing with phospholipase C gamma (PLCG) for binding to estrogen receptor alpha (ESR1), thereby inhibiting downstream estrogen-responsive pathways. SH2D4A also facilitates the recruitment of phosphatases, such as protein phosphatase 1, to modulate phosphotyrosine networks and cytoskeletal dynamics. It plays a role in T-cell development and the regulation of cellular proliferation. Clinically, the downregulation of SH2D4A is implicated in the progression of estrogen-driven breast cancer and other hormone-dependent malignancies, where it acts as a putative tumor suppressor.