人 SH2B2 抗体对
01AB01345
SH2B adaptor protein 2 (SH2B2) is a signaling protein expressed in B lymphocytes, containing pleckstrin homology and Src homology 2 (SH2) domains. It functions as an adapter for tyrosine kinase receptors, involved in multiple signaling pathways. SH2B2 binds to phosphorylated proteins like JAK2, TrkA, and insulin receptors, enhancing their catalytic activity and protecting against dephosphorylation. It forms homo- or hetero-dimers through its N-terminal domain and assembles signaling complexes. SH2B2 plays a role in B cell receptor signaling, binding Shc and Grb2. It acts as a negative regulator of cytokine signaling in collaboration with Cbl. In disease associations, SH2B2 has been linked to hematological neoplasms and solid tumors. Genetic variations in SH2B2 have been associated with response to hepatitis B vaccine and may play a role in blood pressure regulation.
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技术参数
- 靶点基因名
- SH2B2
- 基因别名
- APS
- 蛋白别名
- SH2B adaptor protein 2; SH2B2
- UniProt
- O14492
- 物种
- Human
产品详情
- 靶点名称
- SH2B2
- 蛋白名称
- SH2B adaptor protein 2
- 蛋白别名
- SH2B adapter protein 2; Adapter protein with pleckstrin homology and Src homology 2 domains; SH2 and PH domain-containing adapter protein APS
- 靶点基因名
- SH2B2
- 基因别名
- APS
- UniProt
- O14492
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
SH2B adaptor protein 2 (SH2B2) is a signaling protein expressed in B lymphocytes, containing pleckstrin homology and Src homology 2 (SH2) domains. It functions as an adapter for tyrosine kinase receptors, involved in multiple signaling pathways. SH2B2 binds to phosphorylated proteins like JAK2, TrkA, and insulin receptors, enhancing their catalytic activity and protecting against dephosphorylation. It forms homo- or hetero-dimers through its N-terminal domain and assembles signaling complexes. SH2B2 plays a role in B cell receptor signaling, binding Shc and Grb2. It acts as a negative regulator of cytokine signaling in collaboration with Cbl. In disease associations, SH2B2 has been linked to hematological neoplasms and solid tumors. Genetic variations in SH2B2 have been associated with response to hepatitis B vaccine and may play a role in blood pressure regulation.