人 SGTA 抗体对
01AB02286
Small glutamine rich tetratricopeptide repeat co-chaperone alpha (SGTA) is a ubiquitously expressed co-chaperone that plays a central role in cytosolic protein quality control. It is characterized by an N-terminal dimerization domain and a central array of three tetratricopeptide repeat (TPR) motifs that form a binding groove for hydrophobic or misfolded client proteins. In coordination with the BAG6/UBL4A/GET4 complex and HSP70 family chaperones, SGTA facilitates the proper targeting of these clients to the endoplasmic reticulum or their diversion to degradation pathways. Beyond its role in proteostasis, SGTA modulates steroid and growth hormone receptor signaling and participates in diverse cellular processes, including cell division, apoptosis, and intracellular trafficking.
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技术参数
- 靶点基因名
- SGTA
- 基因别名
- SGT; SGT1
- 蛋白别名
- small glutamine rich tetratricopeptide repeat co-chaperone alpha; SGTA
- UniProt
- O43765
- 物种
- Human
产品详情
- 靶点名称
- SGTA
- 蛋白名称
- small glutamine rich tetratricopeptide repeat co-chaperone alpha
- 蛋白别名
- Small glutamine-rich tetratricopeptide repeat-containing protein alpha; Alpha-SGT; Vpu-binding protein; UBP
- 靶点基因名
- SGTA
- 基因别名
- SGT; SGT1
- UniProt
- O43765
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Small glutamine rich tetratricopeptide repeat co-chaperone alpha (SGTA) is a ubiquitously expressed co-chaperone that plays a central role in cytosolic protein quality control. It is characterized by an N-terminal dimerization domain and a central array of three tetratricopeptide repeat (TPR) motifs that form a binding groove for hydrophobic or misfolded client proteins. In coordination with the BAG6/UBL4A/GET4 complex and HSP70 family chaperones, SGTA facilitates the proper targeting of these clients to the endoplasmic reticulum or their diversion to degradation pathways. Beyond its role in proteostasis, SGTA modulates steroid and growth hormone receptor signaling and participates in diverse cellular processes, including cell division, apoptosis, and intracellular trafficking.