人 Septin-2 抗体对
01AB03022
Septin-2 (SEPT2) is a filament-forming cytoskeletal GTPase that plays a fundamental role in cellular architecture and division. It assembles into hetero-oligomeric complexes to scaffold actin and microtubule networks, essential for cytokinesis, ciliogenesis, and the maintenance of epithelial polarization. SEPT2 localizes to the mitotic spindle to ensure proper chromosome segregation and functions at the base of primary cilia as a diffusion barrier. Dysregulation of SEPT2 is implicated in tumorigenesis, where its overexpression correlates with increased proliferation and invasion in various cancers. Additionally, SEPT2 is critical for endothelial barrier integrity, with altered localization contributing to vascular permeability and inflammatory responses.
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技术参数
- 靶点基因名
- SEPTIN2
- 基因别名
- DIFF6; KIAA0158; NEDD5; SEPT2
- 蛋白别名
- septin 2; Septin-2
- UniProt
- Q15019
- 物种
- Human
产品详情
- 靶点名称
- Septin-2
- 蛋白名称
- septin 2
- 蛋白别名
- Septin-2; Neural precursor cell expressed developmentally down-regulated protein 5; NEDD-5
- 靶点基因名
- SEPTIN2
- 基因别名
- DIFF6; KIAA0158; NEDD5; SEPT2
- UniProt
- Q15019
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Septin-2 (SEPT2) is a filament-forming cytoskeletal GTPase that plays a fundamental role in cellular architecture and division. It assembles into hetero-oligomeric complexes to scaffold actin and microtubule networks, essential for cytokinesis, ciliogenesis, and the maintenance of epithelial polarization. SEPT2 localizes to the mitotic spindle to ensure proper chromosome segregation and functions at the base of primary cilia as a diffusion barrier. Dysregulation of SEPT2 is implicated in tumorigenesis, where its overexpression correlates with increased proliferation and invasion in various cancers. Additionally, SEPT2 is critical for endothelial barrier integrity, with altered localization contributing to vascular permeability and inflammatory responses.