人 SENP2 抗体对
01AB03197
SUMO specific peptidase 2 (SENP2) is a cysteine protease that regulates the SUMOylation status of cellular proteins. It processes SUMO precursors and deconjugates SUMO from substrates, thereby modulating protein function and localization. SENP2 localizes primarily to the nuclear envelope and nuclear pore complex, interacting with nucleoporins to control nuclear transport and pore architecture. It plays an essential role in embryonic development by maintaining gene expression programs and suppressing polycomb-mediated silencing. Loss of SENP2 function disrupts nuclear pore organization and intracellular trafficking, underscoring its importance in cellular homeostasis and development.
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技术参数
- 靶点基因名
- SENP2
- 基因别名
- KIAA1331
- 蛋白别名
- SUMO specific peptidase 2; SENP2
- UniProt
- Q9HC62
- 物种
- Human
产品详情
- 靶点名称
- SENP2
- 蛋白名称
- SUMO specific peptidase 2
- 蛋白别名
- Sentrin-specific protease 2; Axam2; SMT3-specific isopeptidase 2; Smt3ip2; Sentrin/SUMO-specific protease SENP2
- 靶点基因名
- SENP2
- 基因别名
- KIAA1331
- UniProt
- Q9HC62
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
SUMO specific peptidase 2 (SENP2) is a cysteine protease that regulates the SUMOylation status of cellular proteins. It processes SUMO precursors and deconjugates SUMO from substrates, thereby modulating protein function and localization. SENP2 localizes primarily to the nuclear envelope and nuclear pore complex, interacting with nucleoporins to control nuclear transport and pore architecture. It plays an essential role in embryonic development by maintaining gene expression programs and suppressing polycomb-mediated silencing. Loss of SENP2 function disrupts nuclear pore organization and intracellular trafficking, underscoring its importance in cellular homeostasis and development.