抗人 SEMA5A 抗体对
01AB02032
Semaphorin 5A (SEMA5A) is a transmembrane protein that functions as a bifunctional axonal guidance cue, with attractive effects mediated by heparan sulfate proteoglycans and inhibitory effects via chondroitin sulfate proteoglycans. It plays crucial roles in neuronal and vascular development, regulating axon growth and synapse formation. SEMA5A contains a sema domain and seven thrombospondin type-1 repeats, which are important for its interactions with proteoglycans. The protein is expressed in various tissues, including the developing nervous system, and acts through receptors like plexin B3. SEMA5A has been implicated in several neurological disorders, most notably autism spectrum disorder (ASD), where it has been identified as a susceptibility gene. Additionally, alterations in SEMA5A expression have been associated with Cri-du-Chat syndrome and certain cancers, suggesting its potential involvement in diverse pathological processes.
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技术参数
- 靶点基因名
- SEMA5A
- 基因别名
- SEMAF
- 蛋白别名
- semaphorin 5A; SEMA5A
- UniProt
- Q13591
- 物种
- Human
产品详情
- 靶点名称
- SEMA5A
- 蛋白名称
- semaphorin 5A
- 蛋白别名
- Semaphorin-5A; Semaphorin-F; Sema F
- 靶点基因名
- SEMA5A
- 基因别名
- SEMAF
- UniProt
- Q13591
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Semaphorin 5A (SEMA5A) is a transmembrane protein that functions as a bifunctional axonal guidance cue, with attractive effects mediated by heparan sulfate proteoglycans and inhibitory effects via chondroitin sulfate proteoglycans. It plays crucial roles in neuronal and vascular development, regulating axon growth and synapse formation. SEMA5A contains a sema domain and seven thrombospondin type-1 repeats, which are important for its interactions with proteoglycans. The protein is expressed in various tissues, including the developing nervous system, and acts through receptors like plexin B3. SEMA5A has been implicated in several neurological disorders, most notably autism spectrum disorder (ASD), where it has been identified as a susceptibility gene. Additionally, alterations in SEMA5A expression have been associated with Cri-du-Chat syndrome and certain cancers, suggesting its potential involvement in diverse pathological processes.