抗人 SEMA3F 抗体对
01AB00687
Semaphorin 3F (SEMA3F) is a secreted protein belonging to the class 3 semaphorin family, which plays a crucial role in axon guidance and has been implicated in tumor suppression and vascular biology. SEMA3F acts by binding to its receptor, neuropilin-2 (NRP2), to repel endothelial cells and inhibit angiogenesis, thereby suppressing tumor growth and metastasis. The protein is characterized by a sema domain, an immunoglobulin domain, and a basic domain at the C terminus. In the context of disease, SEMA3F expression is consistently downregulated in highly metastatic tumor cells, including those of prostate, bladder, and melanoma cancers, suggesting its role as a tumor suppressor. Additionally, SEMA3F has been shown to maintain endothelial barrier function and inhibit monocyte migration.
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技术参数
- 靶点基因名
- SEMA3F
- 蛋白别名
- semaphorin 3F; SEMA3F
- UniProt
- Q13275
- 物种
- Human
产品详情
- 靶点名称
- SEMA3F
- 蛋白名称
- semaphorin 3F
- 蛋白别名
- Semaphorin-3F; Sema III/F; Semaphorin IV; Sema IV
- 靶点基因名
- SEMA3F
- UniProt
- Q13275
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Semaphorin 3F (SEMA3F) is a secreted protein belonging to the class 3 semaphorin family, which plays a crucial role in axon guidance and has been implicated in tumor suppression and vascular biology. SEMA3F acts by binding to its receptor, neuropilin-2 (NRP2), to repel endothelial cells and inhibit angiogenesis, thereby suppressing tumor growth and metastasis. The protein is characterized by a sema domain, an immunoglobulin domain, and a basic domain at the C terminus. In the context of disease, SEMA3F expression is consistently downregulated in highly metastatic tumor cells, including those of prostate, bladder, and melanoma cancers, suggesting its role as a tumor suppressor. Additionally, SEMA3F has been shown to maintain endothelial barrier function and inhibit monocyte migration.