人 SELL 抗体对
01AB03262
Selectin L (SELL) is a type I transmembrane glycoprotein expressed on leukocytes, functioning as a homing receptor essential for immune surveillance. As a calcium-dependent lectin, it binds sialylated carbohydrates on endothelial ligands, mediating the initial tethering and rolling of leukocytes on activated endothelium and high endothelial venules. This process is critical for leukocyte entry into secondary lymphoid organs and recruitment to sites of inflammation. L-selectin activity is regulated by ectodomain shedding via ADAM17. Dysregulated expression or shedding of L-selectin disrupts leukocyte trafficking and is associated with inflammatory diseases and cancer metastasis.
| 规格 | 起售价 |
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技术参数
- 靶点基因名
- SELL
- 基因别名
- LNHR; LYAM1
- 蛋白别名
- selectin L; SELL
- UniProt
- P14151
- 物种
- Human
产品详情
- 靶点名称
- SELL
- 蛋白名称
- selectin L
- 蛋白别名
- L-selectin; CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL; CD antigen CD62L
- 靶点基因名
- SELL
- 基因别名
- LNHR; LYAM1
- UniProt
- P14151
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Selectin L (SELL) is a type I transmembrane glycoprotein expressed on leukocytes, functioning as a homing receptor essential for immune surveillance. As a calcium-dependent lectin, it binds sialylated carbohydrates on endothelial ligands, mediating the initial tethering and rolling of leukocytes on activated endothelium and high endothelial venules. This process is critical for leukocyte entry into secondary lymphoid organs and recruitment to sites of inflammation. L-selectin activity is regulated by ectodomain shedding via ADAM17. Dysregulated expression or shedding of L-selectin disrupts leukocyte trafficking and is associated with inflammatory diseases and cancer metastasis.