人 SELENBP1 抗体对
01AB02460
Selenium binding protein 1 (SELENBP1) is a highly conserved cytosolic methanethiol oxidase that plays a central role in sulfur metabolism and redox signaling. It catalyzes the copper-dependent oxidation of methanethiol to formaldehyde, hydrogen sulfide, and hydrogen peroxide. SELENBP1 is widely recognized as a tumor suppressor, with its expression frequently downregulated in various malignancies, including lung, colon, and breast cancers, often through epigenetic silencing. Functionally, it modulates key cellular pathways by interacting with cell-cycle regulators like p21, hypoxia-inducible factor 1-alpha (HIF-1α), and the EED/PRC2 epigenetic complex. These interactions allow SELENBP1 to restrain cell proliferation, invasion, and carcinogenic progression, making its expression level a significant prognostic indicator in oncology.
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技术参数
- 靶点基因名
- SELENBP1
- 基因别名
- SBP
- 蛋白别名
- selenium binding protein 1; SELENBP1
- UniProt
- Q13228
- 物种
- Human
产品详情
- 靶点名称
- SELENBP1
- 蛋白名称
- selenium binding protein 1
- 蛋白别名
- Methanethiol oxidase; MTO; 56 kDa selenium-binding protein; SBP56; SP56; Selenium-binding protein 1
- 靶点基因名
- SELENBP1
- 基因别名
- SBP
- UniProt
- Q13228
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Selenium binding protein 1 (SELENBP1) is a highly conserved cytosolic methanethiol oxidase that plays a central role in sulfur metabolism and redox signaling. It catalyzes the copper-dependent oxidation of methanethiol to formaldehyde, hydrogen sulfide, and hydrogen peroxide. SELENBP1 is widely recognized as a tumor suppressor, with its expression frequently downregulated in various malignancies, including lung, colon, and breast cancers, often through epigenetic silencing. Functionally, it modulates key cellular pathways by interacting with cell-cycle regulators like p21, hypoxia-inducible factor 1-alpha (HIF-1α), and the EED/PRC2 epigenetic complex. These interactions allow SELENBP1 to restrain cell proliferation, invasion, and carcinogenic progression, making its expression level a significant prognostic indicator in oncology.