人 SEC23IP 抗体对
01AB02539
SEC23 interacting protein (SEC23IP), also known as p125, is a mammalian-specific protein localized at the endoplasmic reticulum exit sites (ERES) where it plays a critical role in the organization and function of ERES and in COPII-coated vesicle trafficking from the endoplasmic reticulum to the Golgi apparatus. Structurally, SEC23IP has phospholipase A1-like activity and shares homology with phospholipid-modifying proteins, and it directly interacts with VPS13B, recruiting it to ERES–Golgi interface to maintain Golgi structure and facilitate vesicle transport. SEC23IP contains domains such as sterile alpha motif (SAM) and DDHD, with its N-terminal region essential for binding VPS13B. Functional disruption of SEC23IP leads to Golgi fragmentation and disorganization of the ER-Golgi intermediate compartment. Additionally, SEC23IP is important in spermiogenesis and cholesterol trafficking relevant to steroidogenesis.
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技术参数
- 靶点基因名
- SEC23IP
- 蛋白别名
- SEC23 interacting protein; SEC23IP
- UniProt
- Q9Y6Y8
- 物种
- Human
产品详情
- 靶点名称
- SEC23IP
- 蛋白名称
- SEC23 interacting protein
- 蛋白别名
- SEC23-interacting protein; p125
- 靶点基因名
- SEC23IP
- UniProt
- Q9Y6Y8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
SEC23 interacting protein (SEC23IP), also known as p125, is a mammalian-specific protein localized at the endoplasmic reticulum exit sites (ERES) where it plays a critical role in the organization and function of ERES and in COPII-coated vesicle trafficking from the endoplasmic reticulum to the Golgi apparatus. Structurally, SEC23IP has phospholipase A1-like activity and shares homology with phospholipid-modifying proteins, and it directly interacts with VPS13B, recruiting it to ERES–Golgi interface to maintain Golgi structure and facilitate vesicle transport. SEC23IP contains domains such as sterile alpha motif (SAM) and DDHD, with its N-terminal region essential for binding VPS13B. Functional disruption of SEC23IP leads to Golgi fragmentation and disorganization of the ER-Golgi intermediate compartment. Additionally, SEC23IP is important in spermiogenesis and cholesterol trafficking relevant to steroidogenesis.