抗人 SEC16A 抗体对
01AB02763
SEC16 homolog A, endoplasmic reticulum export factor (SEC16A) is a large peripheral membrane protein that serves as a primary molecular scaffold at endoplasmic reticulum exit sites (ERES). It plays a central role in organizing COPII-dependent vesicle budding and facilitating the export of proteins from the ER to the Golgi apparatus. SEC16A interacts with multiple COPII components to define the specific sites of vesicle formation and remains associated with ERES throughout the cell cycle, including mitosis. Beyond constitutive secretion, it participates in unconventional protein secretion under ER stress and contributes to growth factor-regulated secretory upscaling. In specialized cells like adipocytes, SEC16A is involved in the trafficking of specific cargos, such as GLUT4, through its interaction with RAB10, highlighting its importance in both general and regulated secretory pathways.
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技术参数
- 靶点基因名
- SEC16A
- 基因别名
- KIAA0310; SEC16; SEC16L
- 蛋白别名
- SEC16 homolog A, endoplasmic reticulum export factor; SEC16A
- UniProt
- O15027
- 物种
- Human
产品详情
- 靶点名称
- SEC16A
- 蛋白名称
- SEC16 homolog A, endoplasmic reticulum export factor
- 蛋白别名
- Protein transport protein Sec16A; SEC16 homolog A; p250
- 靶点基因名
- SEC16A
- 基因别名
- KIAA0310; SEC16; SEC16L
- UniProt
- O15027
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
SEC16 homolog A, endoplasmic reticulum export factor (SEC16A) is a large peripheral membrane protein that serves as a primary molecular scaffold at endoplasmic reticulum exit sites (ERES). It plays a central role in organizing COPII-dependent vesicle budding and facilitating the export of proteins from the ER to the Golgi apparatus. SEC16A interacts with multiple COPII components to define the specific sites of vesicle formation and remains associated with ERES throughout the cell cycle, including mitosis. Beyond constitutive secretion, it participates in unconventional protein secretion under ER stress and contributes to growth factor-regulated secretory upscaling. In specialized cells like adipocytes, SEC16A is involved in the trafficking of specific cargos, such as GLUT4, through its interaction with RAB10, highlighting its importance in both general and regulated secretory pathways.