人 SDF1 抗体对
01AB02695
Stromal cell-derived factor 1 (CXCL12) is a chemokine that plays a vital role in immune cell trafficking and tissue homeostasis. It primarily acts as a chemoattractant for lymphocytes, monocytes, and hematopoietic stem cells by binding to the CXCR4 receptor, facilitating their migration to sites of inflammation or injury. CXCL12 is crucial in various physiological processes, including hematopoiesis, angiogenesis, and the development of the nervous system. Its dysregulation has been implicated in several diseases. In cancer, CXCL12 promotes tumor progression and metastasis by enhancing the migratory capacity of cancer cells expressing CXCR4, which is observed in cancers such as breast and lung cancer. Additionally, mutations in the CXCL12 gene can influence susceptibility to human immunodeficiency virus (HIV) infection, as certain variants may confer resistance to the virus.
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技术参数
- 靶点基因名
- CXCL12
- 基因别名
- SDF1; SDF1A; SDF1B
- 蛋白别名
- C-X-C motif chemokine ligand 12; SDF1
- UniProt
- P48061
- 物种
- Human
产品详情
- 靶点名称
- SDF1
- 蛋白名称
- C-X-C motif chemokine ligand 12
- 蛋白别名
- Stromal cell-derived factor 1; SDF-1; hSDF-1; C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; hIRH; Pre-B cell growth-stimulating factor; PBSF) [Cleaved into: SDF-1-beta(3-72; SDF-1-alpha(3-67]
- 靶点基因名
- CXCL12
- 基因别名
- SDF1; SDF1A; SDF1B
- UniProt
- P48061
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Stromal cell-derived factor 1 (CXCL12) is a chemokine that plays a vital role in immune cell trafficking and tissue homeostasis. It primarily acts as a chemoattractant for lymphocytes, monocytes, and hematopoietic stem cells by binding to the CXCR4 receptor, facilitating their migration to sites of inflammation or injury. CXCL12 is crucial in various physiological processes, including hematopoiesis, angiogenesis, and the development of the nervous system. Its dysregulation has been implicated in several diseases. In cancer, CXCL12 promotes tumor progression and metastasis by enhancing the migratory capacity of cancer cells expressing CXCR4, which is observed in cancers such as breast and lung cancer. Additionally, mutations in the CXCL12 gene can influence susceptibility to human immunodeficiency virus (HIV) infection, as certain variants may confer resistance to the virus.